In this competing continuation application, we propose to continue following for a final four years a largely intact sample (n=180) thought to be at high-risk for suicidal behavior (a fifth year will be devoted to final analyses and dissemination of results of the study). The individuals in this study have been followed for up to ten years and were ascertained initially as adolescents following psychiatric hospitalization. With this continued period of follow-up, we intend to address several issues not only of theoretical interest, but also with practical clinical implications. The first Specific Aim of this project is to examine an apparent increase in suicidal behavior in this sample in the early- to mid-20's, and the degree to which this increase in suicidal behavior is accounted for by repeat suicidal behavior. In this vein, we also are interested in the degree to which lifetime histories of suicidal behavior in this sample are consistent with a sensitization hypothesis (with increasing frequency and severity of repeat suicide attempts over time, and decreasing relationship between suicide attempts and discrete life events).
The Second Aim of this project is to examine the predictive validity of the clinical characteristics of suicidal behavior. Specifically, given the fact that medical lethality in particular is weighted very highly among mental health professionals in clinical judgments of the risk for later suicidal behavior, we are interested in examining the degree to which the stated intent and medical lethality of suicide attempts are predictive both of the occurrence of later attempts, and of the intent and lethality of subsequent attempts. The final Specific Aim of this project is to examine the real-life (non-suicidal) outcomes (e.g., social dysfunction, school drop-out, job instability, incarceration) among suicidal as contrasted with non-suicidal but psychiatrically impaired individuals. This issue of prognosis is particularly important given several reports in the literature of poor non-suicidal outcomes among suicidal individuals. In this context, we recognize the heterogeneity among suicidal individuals and will use latent class trajectory models to characterize various groups of individuals based on the course of their suicidal ideation and behavior over time. The groups that differ in the courses of their suicidal behavior over time will be contrasted and characterized in terms of risk and protective factors for suicidal behaviors, as well as their risks for various non-suicidal outcomes. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH048762-14
Application #
7010352
Study Section
Biobehavioral and Behavioral Processes 3 (BBBP)
Program Officer
Avenevoli, Shelli A
Project Start
2004-02-10
Project End
2009-01-31
Budget Start
2006-02-01
Budget End
2007-01-31
Support Year
14
Fiscal Year
2006
Total Cost
$335,718
Indirect Cost
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Daniel, Stephanie S; Goldston, David B; Erkanli, Alaattin et al. (2017) Prospective Study of Major Loss Life Events and Risk for Suicidal Thoughts and Behaviors Among Adolescents and Young Adults. Suicide Life Threat Behav 47:436-449
Copeland, William E; Goldston, David B; Costello, E Jane (2017) Adult Associations of Childhood Suicidal Thoughts and Behaviors: A Prospective, Longitudinal Analysis. J Am Acad Child Adolesc Psychiatry 56:958-965.e4
Goldston, David B; Erkanli, Alaattin; Daniel, Stephanie S et al. (2016) Developmental Trajectories of Suicidal Thoughts and Behaviors From Adolescence Through Adulthood. J Am Acad Child Adolesc Psychiatry 55:400-407.e1
Goldston, David B; Daniel, Stephanie S; Erkanli, Alaattin et al. (2015) Suicide attempts in a longitudinal sample of adolescents followed through adulthood: Evidence of escalation. J Consult Clin Psychol 83:253-64
Sapyta, Jeffrey; Goldston, David B; Erkanli, Alaattin et al. (2012) Evaluating the predictive validity of suicidal intent and medical lethality in youth. J Consult Clin Psychol 80:222-31
Goldston, David B; Daniel, Stephanie Sergent; Erkanli, Alaattin et al. (2009) Psychiatric diagnoses as contemporaneous risk factors for suicide attempts among adolescents and young adults: developmental changes. J Consult Clin Psychol 77:281-90
Daniel, Stephanie S; Goldston, David B; Erkanli, Alaattin et al. (2009) Trait anger, anger expression, and suicide attempts among adolescents and young adults: a prospective study. J Clin Child Adolesc Psychol 38:661-71
Goldston, David B; Reboussin, Beth A; Daniel, Stephanie Sergent (2006) Predictors of suicide attempts: state and trait components. J Abnorm Psychol 115:842-9
Goldston, David B (2004) Conceptual issues in understanding the relationship between suicidal behavior and substance use during adolescence. Drug Alcohol Depend 76 Suppl:S79-91