Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH048948-06
Application #
2248499
Study Section
Psychobiological, Biological, and Neurosciences Subcommittee (MHAI)
Project Start
1991-09-30
Project End
1998-05-31
Budget Start
1996-09-01
Budget End
1997-05-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Ovanesov, Mikhail V; Moldovan, Krisztina; Smith, Kimberly et al. (2008) Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus. J Neuroinflammation 5:16
Ovanesov, Mikhail V; Ayhan, Yavuz; Wolbert, Candie et al. (2008) Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection. J Neuroinflammation 5:50
Ovanesov, Mikhail V; Vogel, Michael W; Moran, Timothy H et al. (2007) Neonatal Borna disease virus infection in rats is associated with increased extracellular levels of glutamate and neurodegeneration in the striatum. J Neurovirol 13:185-94
Ovanesov, Mikhail V; Sauder, Christian; Rubin, Steven A et al. (2006) Activation of microglia by borna disease virus infection: in vitro study. J Virol 80:12141-8
Dietz, David; Vogel, Michael; Rubin, Steven et al. (2004) Developmental alterations in serotoninergic neurotransmission in Borna disease virus (BDV)-infected rats: a multidisciplinary analysis. J Neurovirol 10:267-77
Pletnikov, Mikhail V; Rubin, Steven A; Moran, Timothy H et al. (2003) Exploring the cerebellum with a new tool: neonatal Borna disease virus (BDV) infection of the rat's brain. Cerebellum 2:62-70
Pletnikov, Mikhail V; Moran, Timothy H; Carbone, Kathryn M (2002) Borna disease virus infection of the neonatal rat: developmental brain injury model of autism spectrum disorders. Front Biosci 7:d593-607
Carbone, K M; Rubin, S A; Nishino, Y et al. (2001) Borna disease: virus-induced neurobehavioral disease pathogenesis. Curr Opin Microbiol 4:467-75
Pletnikov, M V; Rubin, S A; Carbone, K M et al. (2001) Neonatal Borna disease virus infection (BDV)-induced damage to the cerebellum is associated with sensorimotor deficits in developing Lewis rats. Brain Res Dev Brain Res 126:1-12
Richt, J A; Schmeel, A; Frese, K et al. (1994) Borna disease virus-specific T cells protect against or cause immunopathological Borna disease. J Exp Med 179:1467-73

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