The proposed project will develop a nonhuman primate model of psychosocial influences on disease progression in acquired immune deficiency syndrome (AIDS). In humans, the quality and stability of social life have been implicated as important factors in the progression of diseases such as cancer and cardiovascular disease. HIV disease is often associated with social disruption, and preliminary evidence suggests and psychosocial factors may be related to the progression of HIV infection. Inoculation of rhesus macaques with the simian immunodeficiency virus (SIV) produces a disease considered by many (e.g., IOM, WHO) to be one of the best animal models of HIV infection in humans. Moreover, because of their highly social nature, parallels in psychosocial processes exist between rhesus macaques and humans as well. In the proposed research, we will 1) examine the effects of social stress (i.e., stability/instability of social groups) on behavioral, neuroendocrine, and in vivo measures of immune system functioning in adult male rhesus macaques; and 2) examine the interrelations of these processes in the presence and the absence of concurrent infection with a cloned variant of SIV. By so doing, we will obtain what we believe are the first data on whether a psychosocial intervention can affect the course of an infectious disease in a nonhuman primate. An animal model of the relationship between social stress and disease progression in simian AIDS, involving controlled experimental manipulation, will provide important basic information on the interrelations of social experience and physiological functioning. Such a model is also likely to provide clinically valuable information in the treatment of individuals diagnosed as HIV positive.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH049033-02
Application #
2248571
Study Section
Psychobiological, Biological, and Neurosciences Subcommittee (MHAI)
Project Start
1993-02-01
Project End
1996-01-31
Budget Start
1994-02-01
Budget End
1995-01-31
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of California Davis
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
Capitanio, John P; Cole, Steven W (2015) Social instability and immunity in rhesus monkeys: the role of the sympathetic nervous system. Philos Trans R Soc Lond B Biol Sci 370:
Capitanio, John P (2011) Individual differences in emotionality: social temperament and health. Am J Primatol 73:507-15
Maninger, Nicole; Capitanio, John P; Mason, William A et al. (2010) Acute and chronic stress increase DHEAS concentrations in rhesus monkeys. Psychoneuroendocrinology 35:1055-62
Cole, Steve W; Mendoza, Sally P; Capitanio, John P (2009) Social stress desensitizes lymphocytes to regulation by endogenous glucocorticoids: insights from in vivo cell trafficking dynamics in rhesus macaques. Psychosom Med 71:591-7
Sloan, Erica K; Capitanio, John P; Cole, Steve W (2008) Stress-induced remodeling of lymphoid innervation. Brain Behav Immun 22:15-21
Sloan, Erica K; Capitanio, John P; Tarara, Ross P et al. (2008) Social temperament and lymph node innervation. Brain Behav Immun 22:717-26
Kinnally, Erin L; Whiteman, H J; Mason, W A et al. (2008) Dimensions of response to novelty are associated with social engagement and aggression in adult male rhesus macaques (Macaca mulatta). J Comp Psychol 122:195-203
Sloan, Erica K; Nguyen, Christina T; Cox, Benjamin F et al. (2008) SIV infection decreases sympathetic innervation of primate lymph nodes: the role of neurotrophins. Brain Behav Immun 22:185-94
Capitanio, John P; Emborg, Marina E (2008) Contributions of non-human primates to neuroscience research. Lancet 371:1126-35
Capitanio, John P; Abel, Kristina; Mendoza, Sally P et al. (2008) Personality and serotonin transporter genotype interact with social context to affect immunity and viral set-point in simian immunodeficiency virus disease. Brain Behav Immun 22:676-89

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