Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH049469-05
Application #
2248889
Study Section
Neurosciences Research Review Committee (BPN)
Project Start
1992-06-01
Project End
1997-06-30
Budget Start
1996-06-01
Budget End
1997-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Boston University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Smith, Conor C; Martin, Stella C; Sugunan, Kavitha et al. (2014) A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation. Mol Pharmacol 86:390-8
Smith, Conor C; Gibbs, Terrell T; Farb, David H (2014) Pregnenolone sulfate as a modulator of synaptic plasticity. Psychopharmacology (Berl) 231:3537-56
Kostakis, Emmanuel; Smith, Conor; Jang, Ming-Kuei et al. (2013) The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism. Mol Pharmacol 84:261-74
Kostakis, Emmanuel; Jang, Ming-Kuei; Russek, Shelley J et al. (2011) A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protons. J Neurochem 119:486-96
Eagleson, K L; Gravielle, M C; Schlueter McFadyen-Ketchum, L J et al. (2010) Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changes. Neuroscience 168:797-810
Berezhnoy, D; Gibbs, T T; Farb, D H (2009) Docking of 1,4-benzodiazepines in the alpha1/gamma2 GABA(A) receptor modulator site. Mol Pharmacol 76:440-50
Berezhnoy, Dmytro; Gravielle, Maria C; Downing, Scott et al. (2008) Pharmacological Properties of DOV 315,090, an ocinaplon metabolite. BMC Pharmacol 8:11
Sadri-Vakili, G; Janis, G C; Pierce, R C et al. (2008) Nanomolar concentrations of pregnenolone sulfate enhance striatal dopamine overflow in vivo. J Pharmacol Exp Ther 327:840-5
Whittaker, Matthew T; Gibbs, Terrell T; Farb, David H (2008) Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum. J Neurochem 107:510-21
Jang, Ming-Kuei; Mierke, Dale F; Russek, Shelley J et al. (2004) A steroid modulatory domain on NR2B controls N-methyl-D-aspartate receptor proton sensitivity. Proc Natl Acad Sci U S A 101:8198-203

Showing the most recent 10 out of 19 publications