Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH052974-03
Application #
2252966
Study Section
Psychobiological, Biological, and Neurosciences Subcommittee (MHAI)
Project Start
1994-09-30
Project End
1998-05-31
Budget Start
1996-09-01
Budget End
1997-05-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Pathology
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Roberts, Toni K; Eugenin, Eliseo A; Morgello, Susan et al. (2010) PrPC, the cellular isoform of the human prion protein, is a novel biomarker of HIV-associated neurocognitive impairment and mediates neuroinflammation. Am J Pathol 177:1848-60
Eugenin, Eliseo A; Morgello, Susan; Klotman, Mary E et al. (2008) Human immunodeficiency virus (HIV) infects human arterial smooth muscle cells in vivo and in vitro: implications for the pathogenesis of HIV-mediated vascular disease. Am J Pathol 172:1100-11
Eugenin, Eliseo A; King, Jessie E; Nath, Avindra et al. (2007) HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes. Proc Natl Acad Sci U S A 104:3438-43
King, J E; Eugenin, E A; Buckner, C M et al. (2006) HIV tat and neurotoxicity. Microbes Infect 8:1347-57
Calderon, Tina M; Eugenin, Eliseo A; Lopez, Lillie et al. (2006) A role for CXCL12 (SDF-1alpha) in the pathogenesis of multiple sclerosis: regulation of CXCL12 expression in astrocytes by soluble myelin basic protein. J Neuroimmunol 177:27-39
Buckner, Clarisa M; Luers, Aimee J; Calderon, Tina M et al. (2006) Neuroimmunity and the blood-brain barrier: molecular regulation of leukocyte transmigration and viral entry into the nervous system with a focus on neuroAIDS. J Neuroimmune Pharmacol 1:160-81
D'Aversa, T G; Eugenin, E A; Berman, J W (2005) NeuroAIDS: contributions of the human immunodeficiency virus-1 proteins Tat and gp120 as well as CD40 to microglial activation. J Neurosci Res 81:436-46
D'Aversa, Teresa G; Yu, Karl O A; Berman, Joan W (2004) Expression of chemokines by human fetal microglia after treatment with the human immunodeficiency virus type 1 protein Tat. J Neurovirol 10:86-97
Eugenin, E A; D'Aversa, T G; Lopez, L et al. (2003) MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. J Neurochem 85:1299-311
Ma, Harry; Calderon, Tina M; Kessel, Tamar et al. (2003) Mechanisms of hepatocyte growth factor-mediated vascular smooth muscle cell migration. Circ Res 93:1066-73

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