Childhood bipolar disorders (BP) remain a remarkably understudied area in spite of voluminous literature comprising case reports, small studies, investigations with poorly defined populations, and increasing interest in offspring of parents with BP. To address this paucity of systematic data, we propose a five year, prospective, blindly rated study of the age- specific clinical manifestations and naturalistic course of 7-16 year old children and adolescents with BP disorders. Two contrast groups matched for age, gender, ethnicity, and SES are proposed. One contrast group will have subjects with a diagnosis of ADHD to control for specificity of the findings to BP as opposed to any psychiatric disorder. A second contrast group will be a community case control group to control for reliability of the research assessment procedures and to provide an age-specific normative control. Both the BP and ADHD groups will be enrolled utilizing consecutive case ascertainment from public and private in-patient and out-patient facilities in the St. louis area. The community case control sample will be ascertained by the """"""""acquaintance method."""""""" A total of 270 subjects (90 BP, 90 ADHD, and 90 community case controls) will be entered. Entry will be completed during the first two years of study. Frequency of assessment will be every six months for the BP group to optimize the identification of complex cycling patterns. The two contrast groups will be assessed at baseline and two years after baseline. Assessments will be multi-informant (parents, child/adolescent, teachers); multimodal (respondent based interview, self administered); and multi- domain (psychopathological, psychosocial, academic, cognitive, developmental/maturational, temperament, family history). Findings of the proposed work will fulfill the practitioner's need for diagnostic and prognostic information that can be used to educate families an aid in therapeutic interventions (e.g. knowledge of time course can help determine length and aggressivity of therapy). For investigators, the findings will provide a framework for more focused neurobiological, familial-genetic, and treatment studies. The high rates of suicide an substance dependency in adolescent BP warrant intense efforts to increase our knowledge of childhood onset BP disorders.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
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Child Psychopathology and Treatment Review Committee (CPT)
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Washington University
Schools of Medicine
Saint Louis
United States
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Tandon, Mini; Tillman, Rebecca; Agrawal, Arpana et al. (2016) Trajectories of ADHD severity over 10 years from childhood into adulthood. Atten Defic Hyperact Disord 8:121-30
Tandon, Mini; Tillman, Rebecca; Spitznagel, Edward et al. (2014) Parental Warmth and Risks of Substance Use in Children with Attention-Deficit/Hyperactivity Disorder: Findings from a 10-12 Year Longitudinal Investigation. Addict Res Theory 22:239-250
Gallitano, Amelia L; Tillman, Rebecca; Dinu, Valentin et al. (2012) Family-based association study of early growth response gene 3 with child bipolar I disorder. J Affect Disord 138:387-96
Geller, Barbara; Tillman, Rebecca; Bolhofner, Kristine et al. (2010) Pharmacological and non-drug treatment of child bipolar I disorder during prospective eight-year follow-up. Bipolar Disord 12:164-71
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Geller, Barbara; Tillman, Rebecca; Bolhofner, Kristine et al. (2008) GAD1 single nucleotide polymorphism is in linkage disequilibrium with a child bipolar I disorder phenotype. J Child Adolesc Psychopharmacol 18:25-9
Tillman, Rebecca; Geller, Barbara; Klages, Tricia et al. (2008) Psychotic phenomena in 257 young children and adolescents with bipolar I disorder: delusions and hallucinations (benign and pathological). Bipolar Disord 10:45-55
Geller, Barbara; Tillman, Rebecca; Bolhofner, Kristine (2007) Proposed definitions of bipolar I disorder episodes and daily rapid cycling phenomena in preschoolers, school-aged children, adolescents, and adults. J Child Adolesc Psychopharmacol 17:217-22
Tillman, Rebecca; Geller, Barbara (2007) Diagnostic characteristics of child bipolar I disorder: does the ""Treatment of Early Age Mania (team)"" sample generalize? J Clin Psychiatry 68:307-14

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