The proposed research seeks to illuminate the mechanisms responsible for association in episodic memory-the form of memory that shows the first signs of impairment in normal aging and neurodegenerative disease. In particular, these studies will both test predictions of, and further generalize, the Temporal Context Model (TCM), a mathematical model of recency and association in episodic memory. This model precisely characterizes the mechanism of contextual coding, contextual drift, and associations between items and context. Twelve proposed experiments were designed to achieve four specific aims.
The first aim i s to determine the temporal domain over which associative processes in episodic retrieval are scale invariant.
Aim # 2 is to test the hypothesis that contextual retrieval is the principal cause of associative effects in free recall, and that dissociations in the serial position curve reflect dissociations between cueing with end-of-list context and cueing with retrieved context.
Aim # 3 is to test the hypothesis that free and serial recall share a common associative basis. Using self-initiated recall of lists varying in temporal and positional structure, our last aim is to test the contextual retrieval/compound cueing hypothesis of episodic association. Addressing these basic scientific questions about episodic memory will provide us with important insights into the mechanisms of memory decline both in normal aging and in neurological disease.
| Kahana, Michael J; Aggarwal, Eash V; Phan, Tung D (2018) The variability puzzle in human memory. J Exp Psychol Learn Mem Cogn 44:1857-1863 |
| Weidemann, Christoph T; Kahana, Michael J (2018) Dynamics of brain activity reveal a unitary recognition signal. J Exp Psychol Learn Mem Cogn : |
| Kuhn, Joel R; Lohnas, Lynn J; Kahana, Michael J (2018) A spacing account of negative recency in final free recall. J Exp Psychol Learn Mem Cogn 44:1180-1185 |
| Healey, M Karl; Long, Nicole M; Kahana, Michael J (2018) Contiguity in episodic memory. Psychon Bull Rev : |
| Solomon, E A; Kragel, J E; Gross, R et al. (2018) Medial temporal lobe functional connectivity predicts stimulation-induced theta power. Nat Commun 9:4437 |
| Long, Nicole M; Sperling, Michael R; Worrell, Gregory A et al. (2017) Contextually Mediated Spontaneous Retrieval Is Specific to the Hippocampus. Curr Biol 27:1074-1079 |
| Kragel, James E; Ezzyat, Youssef; Sperling, Michael R et al. (2017) Similar patterns of neural activity predict memory function during encoding and retrieval. Neuroimage 155:60-71 |
| Merkow, Maxwell B; Burke, John F; Ramayya, Ashwin G et al. (2017) Stimulation of the human medial temporal lobe between learning and recall selectively enhances forgetting. Brain Stimul 10:645-650 |
| Solomon, E A; Kragel, J E; Sperling, M R et al. (2017) Widespread theta synchrony and high-frequency desynchronization underlies enhanced cognition. Nat Commun 8:1704 |
| Long, Nicole M; Kahana, Michael J (2017) Modulation of task demands suggests that semantic processing interferes with the formation of episodic associations. J Exp Psychol Learn Mem Cogn 43:167-176 |
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