Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH057068-02
Application #
6052270
Study Section
Project Start
1997-04-01
Project End
2001-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Vaquer-Alicea, Ana Del C; Vázquez-Torres, Rafael; Devarie-Hornedo, Marcos et al. (2018) aPKC-Mediated Persistent Increase in AMPA/NMDA Ratio in the VTA Participates in the Neuroadaptive Signal Necessary to Induce NAc Synaptic Plasticity After Cocaine Administration. Neuroscience 392:129-140
Hsieh, Changchi; Tsokas, Panayiotis; Serrano, Peter et al. (2017) Persistent increased PKM? in long-term and remote spatial memory. Neurobiol Learn Mem 138:135-144
Tsokas, Panayiotis; Hsieh, Changchi; Yao, Yudong et al. (2016) Compensation for PKM? in long-term potentiation and spatial long-term memory in mutant mice. Elife 5:
Ko, Hyoung-Gon; Kim, Ji-Il; Sim, Su-Eon et al. (2016) The role of nuclear PKM? in memory maintenance. Neurobiol Learn Mem 135:50-56
Shao, Charles Y; Sondhi, Rachna; van de Nes, Paula S et al. (2012) PKM? is necessary and sufficient for synaptic clustering of PSD-95. Hippocampus 22:1501-7
Wang, Jun; Meng, Fanli; Cottrell, James E et al. (2012) Metabotropic actions of the volatile anaesthetic sevoflurane increase protein kinase M synthesis and induce immediate preconditioning protection of rat hippocampal slices. J Physiol 590:4093-107
Barry, Jeremy M; Rivard, Bruno; Fox, Steven E et al. (2012) Inhibition of protein kinase Mýý disrupts the stable spatial discharge of hippocampal place cells in a familiar environment. J Neurosci 32:13753-62
Zhang, Y H; Kays, J; Hodgdon, K E et al. (2012) Nerve growth factor enhances the excitability of rat sensory neurons through activation of the atypical protein kinase C isoform, PKMýý. J Neurophysiol 107:315-35
Sacktor, Todd C (2011) How does PKM? maintain long-term memory? Nat Rev Neurosci 12:9-15
Shao, Charles Y; Mirra, Suzanne S; Sait, Hameetha B R et al. (2011) Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced A? and tau pathology in transgenic mouse models of Alzheimer's disease. Acta Neuropathol 122:285-92

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