Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH057436-06
Application #
6651046
Study Section
Integrative, Functional and Cognitive Neuroscience 8 (IFCN)
Program Officer
Aigner, Thomas G
Project Start
1998-05-01
Project End
2006-07-31
Budget Start
2003-08-01
Budget End
2004-07-31
Support Year
6
Fiscal Year
2003
Total Cost
$295,000
Indirect Cost
Name
Ohio State University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
071650709
City
Columbus
State
OH
Country
United States
Zip Code
43210
Demeter, Elise; Sarter, Martin (2013) Leveraging the cortical cholinergic system to enhance attention. Neuropharmacology 64:294-304
Brooks, Julie M; Pershing, Michelle L; Thomsen, Morten S et al. (2012) Transient inactivation of the neonatal ventral hippocampus impairs attentional set-shifting behavior: reversal with an ?7 nicotinic agonist. Neuropsychopharmacology 37:2476-86
Brooks, Julie M; Sarter, Martin; Bruno, John P (2011) Transient inactivation of the neonatal ventral hippocampus permanently disrupts the mesolimbic regulation of prefrontal cholinergic transmission: implications for schizophrenia. Neuropsychopharmacology 36:2477-87
St Peters, Megan; Demeter, Elise; Lustig, Cindy et al. (2011) Enhanced control of attention by stimulating mesolimbic-corticopetal cholinergic circuitry. J Neurosci 31:9760-71
Alexander, Kathleen S; Brooks, Julie M; Sarter, Martin et al. (2009) Disruption of mesolimbic regulation of prefrontal cholinergic transmission in an animal model of schizophrenia and normalization by chronic clozapine treatment. Neuropsychopharmacology 34:2710-20
Kozak, Rouba; Martinez, Vicente; Young, Damon et al. (2007) Toward a neuro-cognitive animal model of the cognitive symptoms of schizophrenia: disruption of cortical cholinergic neurotransmission following repeated amphetamine exposure in attentional task-performing, but not non-performing, rats. Neuropsychopharmacology 32:2074-86
Briand, Lisa A; Gritton, Howard; Howe, William M et al. (2007) Modulators in concert for cognition: modulator interactions in the prefrontal cortex. Prog Neurobiol 83:69-91
Brooks, Julie M; Sarter, Martin; Bruno, John P (2007) D2-like receptors in nucleus accumbens negatively modulate acetylcholine release in prefrontal cortex. Neuropharmacology 53:455-63
Sarter, Martin; Bruno, John P; Parikh, Vinay (2007) Abnormal neurotransmitter release underlying behavioral and cognitive disorders: toward concepts of dynamic and function-specific dysregulation. Neuropsychopharmacology 32:1452-61
Sarter, Martin (2006) Preclinical research into cognition enhancers. Trends Pharmacol Sci 27:602-8

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