Early damage to large portions of the medial temporal lobe has far more severe consequences on the development of cognitive and socioemotional behavior in primates than late damage. The new program of studies described in the proposal is aimed at following these earlier findings in defining which structures in the medial temporal lobe are crucial for the development of normal memory abilities and the formation and establishment of social bonds. We will begin with a study of the effects of early vs. late damage to the hippocampal formation. Earlier studies have often suffered either from the lack of discrete lesions, comprehensive histological analysis or appropriate and sophisticated behavioral assessment, such that the lesion effects reported are inconclusive. The program of studies outlined in this application uses sophisticated MRI-guided excitotoxic hippocampal lesions newly designed memory tasks, extensive characterization of behavioral changes and state of the art anatomical techniques to investigate a) the development of hippocampal functions in monkeys, b) the long-term consequences of early vs. late hippocampal insult on the maturation of memory processes and social bonds, c) the anatomical organization of the efferent projections systems from entorhinal, perirhinal, and parahippocampal areas and, d) the anatomical reorganization of these efferent systems as a result of early hippocampal lesions as compared to adult lesions. Considering that dysfunction of the hippocampal formation contributes to behavioral changes accompanying several devastating neurological disorders, including Dementia, Alzheimer's disease, Schizophrenia and Autism, this unique program of research in monkeys will ultimately lead to the discovery of ways in which such disorders can be alleviated or even eliminated.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
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Cognitive Functional Neuroscience Review Committee (CFN)
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Anderson, Kathleen C
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University of Texas Health Science Center Houston
Schools of Medicine
United States
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Glavis-Bloom, Courtney; Bachevalier, Jocelyne (2018) Neonatal hippocampal lesions facilitate biconditional contextual discrimination learning in monkeys. Behav Neurosci 132:480-496
Ahlgrim, Nathan S; Raper, Jessica; Johnson, Emily et al. (2017) Neonatal perirhinal cortex lesions impair monkeys' ability to modulate their emotional responses. Behav Neurosci 131:359-71
Raper, Jessica; Wilson, Mark; Sanchez, Mar et al. (2017) Increased anxiety-like behaviors, but blunted cortisol stress response after neonatal hippocampal lesions in monkeys. Psychoneuroendocrinology 76:57-66
Payne, Christa; Cirilli, Laetitia; Bachevalier, Jocelyne (2017) An MRI study of the corpus callosum in monkeys: Developmental trajectories and effects of neonatal hippocampal and amygdala lesions. Dev Psychobiol 59:495-506
Weiss, Alison R; Guo, Wendi; Richardson, Rebecca et al. (2017) Intact perceptual ability, but impaired familiarity judgment, after neonatal perirhinal lesions in rhesus macaques. Dev Cogn Neurosci 28:54-64
Malkova, Ludise; Alvarado, Maria C; Bachevalier, Jocelyne (2016) Effects of Separate or Combined Neonatal Damage to the Orbital Frontal Cortex and the Inferior Convexity on Object Recognition in Monkeys. Cereb Cortex 26:618-27
Alvarado, Maria C; Malkova, Ludise; Bachevalier, Jocelyne (2016) Development of relational memory processes in monkeys. Dev Cogn Neurosci 22:27-35
Weiss, Alison R; Bachevalier, Jocelyne (2016) Object and spatial memory after neonatal perirhinal lesions in monkeys. Behav Brain Res 298:210-7
Bachevalier, Jocelyn (2015) The development of hippocampal-dependent memory functions: Theoretical comments on Jab├Ęs and Nelson review (2015). Int J Behav Dev 39:310-314
Zeamer, Alyson; Richardson, Rebecca L; Weiss, Alison R et al. (2015) The development of object recognition memory in rhesus macaques with neonatal lesions of the perirhinal cortex. Dev Cogn Neurosci 11:31-41

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