Animal models suggest that the amygdala has a broad role in modulating emotional learning and memory, as well learned emotional responses. The human amygdala is commonly characterized as being important for most forms of emotional learning and memory. However, the research on the human amygdala to date has only examined a few paradigms and does not support this broader interpretation. The overarching goal of this proposal is to determine the extent of the human arnygdala's involvement in emotional learning and memory and to characterize its role. By examining the role of the human amygdala in a range of emotional learning and memory tasks, we can begin to discover the extent to which these animal models (and popular descriptions) of the amygdala accurately reflect the human amygdala. Two techniques will be used to examine amygdala function in humans. Studies on patients with amygdala damage will indicate if this structure is critical for normal performance on a given task. FMR about studies in normal subjects will provide additional support for the involvement of the amygdala in these tasks and will also indicate other brain regions that may be important. There are three primary goals. First, we hope to confirm the findings of hippocampal modulation with additional paradigms and expand this research by varying the timing and source of emotional stimulus presentation (Section 1). Second, we want to determine how widespread the amvgdala's modulation of memory is; specifically does it extend to other memory systems that underlie skill/habit learning (Section 2), perceptual priming (Section 3) and working memory (Section 4). Third, we hope to specify the amygdala's role in modulating learned emotional responses to stimuli whose emotional significance is learned by means other than fear conditioning. We propose to examine the emotional learning circumstances under which the amygdala is (or is not) critical for normal skin conductance, heart rate, eyeblink startle and subjective emotional responses (Section 5).
| Tambini, Arielle; Rimmele, Ulrike; Phelps, Elizabeth A et al. (2017) Emotional brain states carry over and enhance future memory formation. Nat Neurosci 20:271-278 |
| Hartley, Catherine A; Gorun, Alyson; Reddan, Marianne C et al. (2014) Stressor controllability modulates fear extinction in humans. Neurobiol Learn Mem 113:149-56 |
| Ferneyhough, Emma; Kim, Min K; Phelps, Elizabeth A et al. (2013) Anxiety modulates the effects of emotion and attention on early vision. Cogn Emot 27:166-76 |
| Schiller, Daniela; Kanen, Jonathan W; LeDoux, Joseph E et al. (2013) Extinction during reconsolidation of threat memory diminishes prefrontal cortex involvement. Proc Natl Acad Sci U S A 110:20040-5 |
| Brosch, Tobias; Bar-David, Eyal; Phelps, Elizabeth A (2013) Implicit race bias decreases the similarity of neural representations of black and white faces. Psychol Sci 24:160-6 |
| Brosch, Tobias; Schiller, Daniela; Mojdehbakhsh, Rachel et al. (2013) Neural mechanisms underlying the integration of situational information into attribution outcomes. Soc Cogn Affect Neurosci 8:640-6 |
| Raio, Candace M; Carmel, David; Carrasco, Marisa et al. (2012) Nonconscious fear is quickly acquired but swiftly forgotten. Curr Biol 22:R477-9 |
| Rimmele, Ulrike; Davachi, Lila; Phelps, Elizabeth A (2012) Memory for time and place contributes to enhanced confidence in memories for emotional events. Emotion 12:834-46 |
| Levens, Sara M; Devinsky, Orrin; Phelps, Elizabeth A (2011) Role of the left amygdala and right orbital frontal cortex in emotional interference resolution facilitation in working memory. Neuropsychologia 49:3201-12 |
| Rimmele, Ulrike; Davachi, Lila; Petrov, Radoslav et al. (2011) Emotion enhances the subjective feeling of remembering, despite lower accuracy for contextual details. Emotion 11:553-62 |
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