The ventral ('limbic-related) striatum mediates motivated behavior, and is considered an important anatomic Substrate of psychosis. The amygdala, a prominent limbic structure, links complex sensory stimuli to their emotional significance. One way the ventral striatum can be defined is based on inputs from structuresthat mediate emotional processing the amygdala; orbitomedial prefrontal regions linked to the amygdala, and the dorsal tier dopamine (DA) neurons. The ventral striatal 'shell' is a unique subregion that receives restricted inputs from these structures, and is charactenzed by 1. Relatively low calbindin-Dk28 (CaBP) staining, 2. Multiple cellular ('interface') islands with differential distributions of substance F, enkephalin, acetyicholinesterase (AchE), tyrosine hydroxylase (TH), and D1 mRNA, 3. Regions of precise overlap between amygdaloid afferents and cell clusters associated with specific transmitters, 4. Regions of tight overlap between amygdaloid and cortical afferents. We hypothesize that the caudoventral striatum and adjacent amygdalostriatal area (Astr) is a special part of the ventral 'limbic' striatum that is devoted to temporal lobe inputs, based on similar criteria. The temporal lobes mediate auditory and visual processing, are interconnected with the amygdala, and are a site of abnormalities in schizophrenia. Our preliminary data suggest that, like the ventral striatum, the caudoventral striatum/Astr area: 1. Receives afferents from brain structures mediating emotion: amygdala, specific regions of cortex linked to the amygdala, and the DA neurons. 2. Receives input from a caudal component of the 'dorsal tier' of DA neurons 3. Has a CaBP-poor region, and multiple cellular islands associated with varying distributions of substance F, enkephalin, AchE, TH, and D1 mRNA, similar to that found in the shell. The first goal of these studies is to determine whether the caudoventral striatum/Astr area is part of the ventral striatum based on connectional, cytoarchitectural, and histochemical features.
Our second aim i s to examine the hypothesis that the amygdala projects to cellular clusters containing substance P and Dl receptor mRNA in the caudoventral striatal/Astr area, and is therfore in a position to activate these transmitter/receptor specific pathways.
Our third aim i s to determine whether amygdaloid and temporal cortical inputs converge in the caudoventral striatum/Astr area. The results of these studies will provide an anatomic framework for understanding how emotionally significant auditory and visual information is processed in the striatum.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH063291-01
Application #
6319349
Study Section
Special Emphasis Panel (ZRG1-BDCN-6 (01))
Project Start
2001-04-01
Project End
2004-03-31
Budget Start
2001-04-01
Budget End
2002-03-31
Support Year
1
Fiscal Year
2001
Total Cost
$279,125
Indirect Cost
Name
University of Rochester
Department
Psychiatry
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Kelly, E A; Fudge, J L (2018) The neuroanatomic complexity of the CRF and DA systems and their interface: What we still don't know. Neurosci Biobehav Rev 90:247-259
Oler, Jonathan A; Tromp, Do P M; Fox, Andrew S et al. (2017) Connectivity between the central nucleus of the amygdala and the bed nucleus of the stria terminalis in the non-human primate: neuronal tract tracing and developmental neuroimaging studies. Brain Struct Funct 222:21-39
Fudge, Julie L; Kelly, Emily A; Pal, Ria et al. (2017) Beyond the Classic VTA: Extended Amygdala Projections to DA-Striatal Paths in the Primate. Neuropsychopharmacology 42:1563-1576
Kalin, Ned H; Fox, Andrew S; Kovner, Rothem et al. (2016) Overexpressing Corticotropin-Releasing Factor in the Primate Amygdala Increases Anxious Temperament and Alters Its Neural Circuit. Biol Psychiatry 80:345-55
Torrisi, Salvatore; O'Connell, Katherine; Davis, Andrew et al. (2015) Resting state connectivity of the bed nucleus of the stria terminalis at ultra-high field. Hum Brain Mapp 36:4076-88
deCampo, Danielle M; Fudge, Julie L (2013) Amygdala projections to the lateral bed nucleus of the stria terminalis in the macaque: comparison with ventral striatal afferents. J Comp Neurol 521:3191-216
Cho, Youngsun T; Ernst, Monique; Fudge, Julie L (2013) Cortico-amygdala-striatal circuits are organized as hierarchical subsystems through the primate amygdala. J Neurosci 33:14017-30
Fudge, J L; deCampo, D M; Becoats, K T (2012) Revisiting the hippocampal-amygdala pathway in primates: association with immature-appearing neurons. Neuroscience 212:104-19
deCampo, Danielle M; Fudge, Julie L (2012) Where and what is the paralaminar nucleus? A review on a unique and frequently overlooked area of the primate amygdala. Neurosci Biobehav Rev 36:520-35
Cho, Y T; Fudge, J L (2010) Heterogeneous dopamine populations project to specific subregions of the primate amygdala. Neuroscience 165:1501-18

Showing the most recent 10 out of 18 publications