We do not yet understand how brain and cognitive processes integrate to support the emergence of healthy adult-level cognitive control of behavior, subsequently;our understanding of neurodevelopmental models of psychiatric illnesses is also limited. The broad goal of this application is to gain knowledge regarding the neurobiological basis of cognitive development from childhood to adulthood. We propose to use well-established cognitive neuroscience methods, devised to investigate the link between basic cognitive processes and brain processes. Oculomotor and neuropsychological tasks will be performed by 132 eight to 22 year-old healthy subjects in a hybrid cross-sectional longitudinal design that will span 15 years of development. A subgroup of 88 subjects will also participate in whole-brain fMRI and DTI studies.
The aim of this proposal is to delineate the shape, peak, and variability of cognitive development, characterize how it is subserved by changes in brain activation, and identify the maturation of brain connectivity that supports the transition to adult level brain circuitry. Based on our preliminary findings from an NIMH-funded K01 award and review of the literature, we hypothesize that response inhibition, working memory, and multi-level cognitive processes, such as high level planning, will continue to improve throughout adolescence as widely distributed brain function integrating cortical and subcortical systems emerges supported by increases in indices of myelination connecting these regions. Different rates of development will be characterized by a unique profile of subject characteristics related to puberty, IQ, and gender. Developmental improvements in the performance of multi-level cognitive tasks will be supported by the independent maturation of response inhibition and working memory. This work will result in a normative template of the maturation of basic cognitive control, which will be significant in identifying impairments of cognitive maturation in developmental psychopathologies, including schizophrenia and mood disorders that emerge in adolescence.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH067924-07
Application #
7907755
Study Section
Cognition and Perception Study Section (CP)
Program Officer
Osborn, Bettina D
Project Start
2004-07-01
Project End
2011-07-31
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
7
Fiscal Year
2010
Total Cost
$545,653
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Dickie, Erin W; Ameis, Stephanie H; Shahab, Saba et al. (2018) Personalized Intrinsic Network Topography Mapping and Functional Connectivity Deficits in Autism Spectrum Disorder. Biol Psychiatry 84:278-286
Ordaz, Sarah J; Fritz, Barbara L; Forbes, Erika E et al. (2018) The influence of pubertal maturation on antisaccade performance. Dev Sci 21:e12568
Di Martino, Adriana; O'Connor, David; Chen, Bosi et al. (2017) Enhancing studies of the connectome in autism using the autism brain imaging data exchange II. Sci Data 4:170010
Montez, David Florentino; Calabro, Finnegan J; Luna, Beatriz (2017) The expression of established cognitive brain states stabilizes with working memory development. Elife 6:
Simmonds, Daniel J; Hallquist, Michael N; Luna, Beatriz (2017) Protracted development of executive and mnemonic brain systems underlying working memory in adolescence: A longitudinal fMRI study. Neuroimage 157:695-704
Hawes, Samuel W; Chahal, Rajpreet; Hallquist, Michael N et al. (2017) Modulation of reward-related neural activation on sensation seeking across development. Neuroimage 147:763-771
Hwang, Kai; Ghuman, Avniel S; Manoach, Dara S et al. (2016) Frontal preparatory neural oscillations associated with cognitive control: A developmental study comparing young adults and adolescents. Neuroimage 136:139-48
O'Hearn, Kirsten; Velanova, Katerina; Lynn, Andrew et al. (2016) Abnormalities in brain systems supporting individuation and enumeration in autism. Autism Res 9:82-96
Murty, Vishnu P; Calabro, Finnegan; Luna, Beatriz (2016) The role of experience in adolescent cognitive development: Integration of executive, memory, and mesolimbic systems. Neurosci Biobehav Rev 70:46-58
Valk, Sofie L; Di Martino, Adriana; Milham, Michael P et al. (2015) Multicenter mapping of structural network alterations in autism. Hum Brain Mapp 36:2364-73

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