Abstract

The ability to time underlies adaptive behavior. Skilled motor sequences are carefully timed. Decisions about whether or not to take an action depend on knowledge of when they are appropriate. Memories for how long actions usually take underlies most ordinary activity such as planning a day or knowing how long it takes to cross a street. This learning of time is largely automatic is a foundation of behavioral organization. Disordered timing and distorted anticipation are associated with a number of psychiatric disorders including attention deficit hyperactivity disorder, schizophrenia and depression. The purpose of this grant is to understand how times are learned, remembered and used to guide behavior.

Public Health Relevance

There are deficits in timing and anticipation in many behavior disorders. Depression, schizophrenia and attention-deficit-hyperactivity disorder are all associated with distortions in time perception and changes in the capacity to anticipate predictable events. Drug-taking and other habitual high-risk behaviors are associated with diminished capacity to anticipate long-term consequences. An understanding of the mechanisms of anticipatory learning will lead to more widespread and effective behavioral and biological treatments.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH068073-10
Application #
8437082
Study Section
Biobehavioral Regulation, Learning and Ethology Study Section (BRLE)
Program Officer
Rossi, Andrew
Project Start
2003-03-05
Project End
2015-02-28
Budget Start
2013-03-01
Budget End
2015-02-28
Support Year
10
Fiscal Year
2013
Total Cost
$355,974
Indirect Cost
$80,008

  Institution

Name
Barnard College
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
068119601
City
New York
State
NY
Country
United States
Zip Code
10027

  Publications

Bailey, Matthew R; Goldman, Olivia; Bello, Estefanía P et al. (2018) An Interaction between Serotonin Receptor Signaling and Dopamine Enhances Goal-Directed Vigor and Persistence in Mice. J Neurosci 38:2149-2162
Cassidy, Clifford M; Balsam, Peter D; Weinstein, Jodi J et al. (2018) A Perceptual Inference Mechanism for Hallucinations Linked to Striatal Dopamine. Curr Biol 28:503-514.e4
Demireva, Elena Y; Suri, Deepika; Morelli, Emanuela et al. (2018) 5-HT2C receptor blockade reverses SSRI-associated basal ganglia dysfunction and potentiates therapeutic efficacy. Mol Psychiatry :
Nautiyal, Katherine M; Wall, Melanie M; Wang, Shuai et al. (2017) Genetic and Modeling Approaches Reveal Distinct Components of Impulsive Behavior. Neuropsychopharmacology 42:1182-1191
Drew, Michael R; Walsh, Carolyn; Balsam, Peter D (2017) Rescaling of temporal expectations during extinction. J Exp Psychol Anim Learn Cogn 43:1-14
Matamales, Miriam; Skrbis, Zala; Bailey, Matthew R et al. (2017) A corticostriatal deficit promotes temporal distortion of automatic action in ageing. Elife 6:
Simpson, Eleanor H; Balsam, Peter D (2016) The Behavioral Neuroscience of Motivation: An Overview of Concepts, Measures, and Translational Applications. Curr Top Behav Neurosci 27:1-12
Bailey, Matthew R; Simpson, Eleanor H; Balsam, Peter D (2016) Neural substrates underlying effort, time, and risk-based decision making in motivated behavior. Neurobiol Learn Mem 133:233-256
Tarullo, Amanda R; Isler, Joseph R; Condon, Carmen et al. (2016) Neonatal eyelid conditioning during sleep. Dev Psychobiol 58:875-882
Kirkpatrick, Kimberly; Balsam, Peter D (2016) Associative learning and timing. Curr Opin Behav Sci 8:181-185

Showing the most recent 10 out of 54 publications