Advances in HIV treatment and prevention have led to millions of perinatally HIV-infected (PHIV) and perinatally HIV-exposed, but uninfected (PHEU) children surviving into adolescence and young adulthood. Young adulthood can be a precarious developmental period, and PHIV young adults (YA) are at particularly high risk for mental health problems, risk behaviors, and difficulties achieving adult milestones due to a ?perfect storm? of compromised health, life stressors, and neurocognitive deficits. These risks are exacerbated by inadequately controlled HIV, and psychosocial stressors encountered by both PHIV and PHEU YA, leading to chronic inflammatory responses that compromise psychiatric function, neurocognition, and overall health outcomes. For the past 15 years, CASAH has followed 340 PHIV and PHEU youth (enrolled at ages 9-16 years) living in vulnerable communities in New York City, documenting risk and resilience across childhood, adolescence, and emerging adulthood. This competing continuation of CASAH (R01-MH69133-15), CASAH4, will follow this cohort through young adulthood (20s-early 30s), leading to one of the most comprehensive longitudinal data sets on mental health, health risk behavior, and achievement of adult milestones among PHIV and PHEU YA. Guided by Social Action Theory (SAT), CASAH4 offers a unique opportunity leverage our unique longitudinal data set to understand the impact of both lifelong HIV infection and also contextual, social-regulation, and self-regulation determinants of mental health, health risk behaviors, and adult milestone achievement. In CASAH4 we aim to 1) examine the impact of HIV infection on behavioral health outcomes (e.g., mental health, sexual risk, substance use, adherence) and achievement of adult milestones (e.g., education, vocation, independence); 2) examine how SAT-informed risk and protective factors affect YA behavioral health and achievement of adult milestones; 3) explore trajectories of behavioral health across adolescence and young adulthood and SAT-informed predictors of these trajectories; and 4) compare behavioral health outcomes and their SAT-informed predictors among youth across three global cohorts by PHIV-status at early (9-12 years), middle (13-15 years), and late (16-19 years) adolescence. Building on our previous work, we will enhance our assessment of adult milestones, psychiatric function, and neurocognitive function, and will add biomedical health indicators (inflammation and immune activation biomarkers associated with psychiatric disorders and neurocognitive function) to the HIV RNA viral load and CD4+ cell count already collected. CASAH has made significant contributions to research on risk and resilience in PHIV and PHEU youth with 117 publications and 65 scientific presentations, and has directly informed mental- health and HIV-prevention interventions and service systems in the US and abroad. With a multidisciplinary and cross-cultural team, we have a unique opportunity to extended our work into young adulthood, to identify modifiable predictors of behavioral risk trajectories and young adult function, and to inform the development of timely, targeted, and evidence-based interventions for vulnerable PHIV and PHEU across global contexts.
The pediatric HIV epidemic is rapidly becoming one of young adulthood with millions of perinatally HIV-infected (PHIV) and perinatally HIV-exposed but uninfected (PHEU) children surviving into young adulthood globally. PHIV and PHEU young adults (YA) face a ?perfect storm? of risk factors that can lead to poor behavioral health outcomes and difficulty achieving adult milestones, and PHIV YA may be additionally vulnerable to chronic inflammatory responses (due to inadequately controlled HIV and psychosocial stressors) that compromise psychiatric function, neurocognition, and overall health outcomes. Young adulthood is also a period of significant opportunity to promote healthy development and optimize adult functioning and CASAH4 will contribute to this critical research gap by examining the impact of both lifelong HIV infection and contextual, social-regulation, and self-regulation determinants of mental health, health risk behaviors, and adult milestone achievement to inform the development of timely, targeted, and evidence-based interventions for vulnerable PHIV and PHEU across global contexts.
|Bucek, Amelia; Leu, Cheng-Shiun; Benson, Stephanie et al. (2018) Psychiatric Disorders, Antiretroviral Medication Adherence and Viremia in a Cohort of Perinatally HIV-Infected Adolescents and Young Adults. Pediatr Infect Dis J 37:673-677|
|Elkington, Katherine S; Peters, Zachary; Choi, C Jean et al. (2018) Predicting Arrest in a Sample of Youth Perinatally Exposed to HIV: The Intersection of HIV and Key Contextual Factors. AIDS Behav 22:3234-3243|
|Benson, Stephanie; Elkington, Katherine S; Leu, Cheng-Shiun et al. (2018) Association Between Psychiatric Disorders, Substance Use, and Sexual Risk Behaviors in Perinatally HIV-Exposed Youth. J Assoc Nurses AIDS Care 29:538-549|
|Mutumba, M; Elkington, K S; Bauermeister, J A et al. (2017) Changes in Substance Use Symptoms Across Adolescence in Youth Perinatally Infected with HIV. AIDS Behav 21:1117-1128|
|Weintraub, Amy; Mellins, Claude A; Warne, Patricia et al. (2017) Patterns and Correlates of Serostatus Disclosure to Sexual Partners by Perinatally-Infected Adolescents and Young Adults. AIDS Behav 21:129-140|
|Raymond, Jeannette F; Bucek, Amelia; Dolezal, Curtis et al. (2017) Use of Unannounced Telephone Pill Counts to Measure Medication Adherence Among Adolescents and Young Adults Living With Perinatal HIV Infection. J Pediatr Psychol 42:1006-1015|
|Marhefka, Stephanie L; Green, Shana M; Sharma, Vinita et al. (2017) ""They said ""be careful'"": sexual health communication sources and messages for adolescent girls living with perintally-acquired HIV infection. AIDS Care 29:1265-1269|
|Elkington, Katherine S; Cruz, Jennifer E; Warne, Patricia et al. (2016) Marijuana Use and Psychiatric Disorders in Perinatally HIV-Exposed Youth: Does HIV Matter? J Pediatr Psychol 41:277-86|
|Mutumba, Massy; Bauermeister, Jose A; Elkington, Katherine S et al. (2016) A Prospective Longitudinal Study of Mental Health Symptoms Among Perinatally HIV-Infected and HIV-Exposed but Uninfected Urban Youths. J Adolesc Health 58:460-466|
|Evans, Shenell D; Mellins, Claude Ann; Leu, Cheng-Shiun et al. (2015) HIV treatment adherence measurement and reporting concordance in youth with perinatally acquired HIV infection and their caregivers. AIDS Patient Care STDS 29:43-51|
Showing the most recent 10 out of 32 publications