The capacity to acquire and retrieve memories of unique events is termed 'episodic memory'. Disabling impairments of episodic memory are prominent in several common neurological conditions, including Alzheimer's disease and Traumatic Brain Injury, and it has been proposed that episodic memory dysfunction plays a role in common psychiatric disorders such as post-traumatic stress disorder and depression. The characterization of episodic memory impairment and dysfunction, and the development of rational remedial measures, require an understanding of the cognitive operations that support episodic memory and their neural underpinnings. The proposed research will contribute to this understanding through a cognitive neuroscience investigation of two aspects of episodic memory retrieval: the processes engaged i) when a cue is employed in an attempt to retrieve episodic information from memory, and ii) when a retrieval attempt is successful. The research will combine behavioral methods with two methods for non-invasive measurement of brain activity, event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI). Together, the methods will be employed to further understanding of cue processing and successful episodic retrieval. With regard to cue processing, issues to be addressed include: the circumstances under which individuals can bias cue processing (adopt a 'retrieval orientation') in service of a specific retrieval goal;the neural correlates of the maintenance of specific retrieval orientations;and the functional significance of differential neural activity elicited by cues employed in service of different retrieval goals. In the case of successful retrieval, issues include: the enerality of previously described neural correlates of episodic retrieval;the sensitivity of these neural correlates to the content and amount of information retrieved;and comparison of existing recognition-based procedures for investigating episodic retrieval to results obtained with a recall procedure.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
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Cognition and Perception Study Section (CP)
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Osborn, Bettina D
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University of California Irvine
Other Basic Sciences
Schools of Arts and Sciences
United States
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King, Danielle R; de Chastelaine, Marianne; Rugg, Michael D (2018) Recollection-related increases in functional connectivity across the healthy adult lifespan. Neurobiol Aging 62:1-19
Koen, Joshua D; Thakral, Preston P; Rugg, Michael D (2018) Transcranial magnetic stimulation of the left angular gyrus during encoding does not impair associative memory performance. Cogn Neurosci 9:127-138
King, Danielle R; Chastelaine, Marianne de; Elward, Rachael L et al. (2018) Dissociation between the neural correlates of recollection and familiarity in the striatum and hippocampus: Across-study convergence. Behav Brain Res 354:1-7
Rugg, Michael D; King, Danielle R (2018) Ventral lateral parietal cortex and episodic memory retrieval. Cortex 107:238-250
Thakral, Preston P; Wang, Tracy H; Rugg, Michael D (2017) Decoding the content of recollection within the core recollection network and beyond. Cortex 91:101-113
Thakral, Preston P; Wang, Tracy H; Rugg, Michael D (2015) Cortical reinstatement and the confidence and accuracy of source memory. Neuroimage 109:118-29
King, Danielle R; de Chastelaine, Marianne; Elward, Rachael L et al. (2015) Recollection-related increases in functional connectivity predict individual differences in memory accuracy. J Neurosci 35:1763-72
Elward, Rachael L; Rugg, Michael D (2015) Retrieval Goal Modulates Memory for Context. J Cogn Neurosci 27:2529-40
Thakral, Preston P; Yu, Sarah S; Rugg, Michael D (2015) The hippocampus is sensitive to the mismatch in novelty between items and their contexts. Brain Res 1602:144-52
Elward, Rachael L; Vilberg, Kaia L; Rugg, Michael D (2015) Motivated Memories: Effects of Reward and Recollection in the Core Recollection Network and Beyond. Cereb Cortex 25:3159-66

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