The proposed research entails anatomical, biochemical, and ablation- behavior analyses of neocortex in neurologically primitive mammals. The long term objective is to discover the contribution of sensory, association, and motor cortex to the neurological and psychological adjustment of man and animals to their environment.
The specific aims i nclude the assessment of the structure and function of major areas of neocortex in a number of neurologically generalized mammals (including opossums, armadillos, rabbits, rats, hedgehogs, tree shrews, lemurs, and bushbabies) specifically selected for their sequential common ancestry with Primates, in order to allow inferences to the neurological and psychological condition of the extinct animals in the Primate ancestral lineage. The methods include anatomical tract-tracing techniques to determine the changes in the location, extent, and connections of sensory and motor areas, receptor-binding and immunohistochemical techniques to determine changes in the biochemical characteristics of that same areas, and ablation-behavior techniques to determine the changes in the behavioral contributions of the areas. In this manner the evolutionary development of Primate neocortex is traced from its most primitive mammalian form to its current form in an attempt to understand the contributions of its many parts.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS007726-26
Application #
3393640
Study Section
Neurology B Subcommittee 2 (NEUB)
Project Start
1978-07-01
Project End
1999-11-30
Budget Start
1992-12-01
Budget End
1993-11-30
Support Year
26
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Florida State University
Department
Type
Schools of Arts and Sciences
DUNS #
020520466
City
Tallahassee
State
FL
Country
United States
Zip Code
32306
Jablonski, Angela M; Lamitina, Todd; Liachko, Nicole F et al. (2015) Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance. J Neurosci 35:14286-306
Masterton, R B (1997) Neurobehavioral studies of the central auditory system. Ann Otol Rhinol Laryngol Suppl 168:31-4
Frost, S B; Masterton, R B (1994) Hearing in primitive mammals: Monodelphis domestica and Marmosa elegans. Hear Res 76:67-72
Masterton, R B; Granger, E M; Glendenning, K K (1994) Role of acoustic striae in hearing: mechanism for enhancement of sound detection in cats. Hear Res 73:209-22
Nudo, R J; Sutherland, D P; Masterton, R B (1993) Inter- and intra-laminar distribution of tectospinal neurons in 23 mammals. Brain Behav Evol 42:1-23
Masterton, R B (1993) Central auditory system. ORL J Otorhinolaryngol Relat Spec 55:159-63
Nudo, R J; Masterton, R B (1989) Descending pathways to the spinal cord: II. Quantitative study of the tectospinal tract in 23 mammals. J Comp Neurol 286:96-119
Masterton, R B; Granger, E M (1988) Role of the acoustic striae in hearing: contribution of dorsal and intermediate striae to detection of noises and tones. J Neurophysiol 60:1841-60
Nudo, R J; Masterton, R B (1988) Descending pathways to the spinal cord: a comparative study of 22 mammals. J Comp Neurol 277:53-79
Hutson, K A; Masterton, R B (1986) The sensory contribution of a single vibrissa's cortical barrel. J Neurophysiol 56:1196-223

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