The long term objective of the proposed research is to discover the changing behavioral roles which parallel the evolution of sensory, association, and motor cortex in the historical lineage leading to Primates and Man. The general strategy begins with a description of the structure-function relationships of major areas of neocortex in a number of neurologically generalized mammals specifically selected for their sequential common ancestry with Primates. The methods have included cytoarchitectonic and anatomical tract-tracing techniques to determine the successive changes in the location, extent, and connections of sensory and motor areas and then receptor-binding and immunohistochemical techniques for neurotransmitter-identification of the afferents and efferents for the same areas. The results of these structural studies are then used to guide comparative behavioral studies and ablation-behavior experiments to determine the history of the behavioral contributions of the several areas. In this manner the evolutionary development of the neocortex is traced from its most primitive mammalian form to the Primate form in an attempt to understand the contributions of its many parts. In this application they focus on the behavioral consequences of the three most radical evolutionary changes in form which have been already uncovered.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Project (R01)
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Biopsychology Study Section (BPO)
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Broman, Sarah H
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Florida State University
Schools of Arts and Sciences
United States
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Jablonski, Angela M; Lamitina, Todd; Liachko, Nicole F et al. (2015) Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance. J Neurosci 35:14286-306
Masterton, R B (1997) Neurobehavioral studies of the central auditory system. Ann Otol Rhinol Laryngol Suppl 168:31-4
Frost, S B; Masterton, R B (1994) Hearing in primitive mammals: Monodelphis domestica and Marmosa elegans. Hear Res 76:67-72
Masterton, R B; Granger, E M; Glendenning, K K (1994) Role of acoustic striae in hearing: mechanism for enhancement of sound detection in cats. Hear Res 73:209-22
Nudo, R J; Sutherland, D P; Masterton, R B (1993) Inter- and intra-laminar distribution of tectospinal neurons in 23 mammals. Brain Behav Evol 42:1-23
Masterton, R B (1993) Central auditory system. ORL J Otorhinolaryngol Relat Spec 55:159-63
Nudo, R J; Masterton, R B (1989) Descending pathways to the spinal cord: II. Quantitative study of the tectospinal tract in 23 mammals. J Comp Neurol 286:96-119
Masterton, R B; Granger, E M (1988) Role of the acoustic striae in hearing: contribution of dorsal and intermediate striae to detection of noises and tones. J Neurophysiol 60:1841-60
Nudo, R J; Masterton, R B (1988) Descending pathways to the spinal cord: a comparative study of 22 mammals. J Comp Neurol 277:53-79
Hutson, K A; Masterton, R B (1986) The sensory contribution of a single vibrissa's cortical barrel. J Neurophysiol 56:1196-223

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