Abstract

The purpose of this research is to contribute to our understanding of the neuronal machinery responsible for learning and response selection in complex, integrated behavioral repertoires. These related problems are to be studied in a relatively simple system, the lateral giant escape reaction circuit of the crayfish, which is subject to a variety of forms of control and modulation. Behavioral, electrophysiological, and anatomical research is proposed on (1) the cellular basis of sensitization, long-term potentiation, and associative learning, (2) modulatory circuitry that is involved in integrating lateral giant escape into the behavioral repertoire of the animal, and (3) effects of neural activity on synapse formation during regeneration following injury.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS008108-21
Application #
3393712
Study Section
Biopsychology Study Section (BPO)
Project Start
1978-07-01
Project End
1993-06-30
Budget Start
1988-07-01
Budget End
1989-06-30
Support Year
21
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Arts and Sciences
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Lee, Sun Hee Cho; Taylor, Karen; Krasne, Franklin B (2008) Reciprocal stimulation of decay between serotonergic facilitation and depression of synaptic transmission. J Neurophysiol 100:1113-26
Vu, E T; Lee, S C; Krasne, F B (1993) The mechanism of tonic inhibition of crayfish escape behavior: distal inhibition and its functional significance. J Neurosci 13:4379-93
Lee, S C; Krasne, F B (1993) Ultrastructure of the circuit providing input to the crayfish lateral giant neurons. J Comp Neurol 327:271-88
Vu, E T; Krasne, F B (1993) Crayfish tonic inhibition: prolonged modulation of behavioral excitability by classical GABAergic inhibition. J Neurosci 13:4394-402
Miller, M W; Vu, E T; Krasne, F B (1992) Cholinergic transmission at the first synapse of the circuit mediating the crayfish lateral giant escape reaction. J Neurophysiol 68:2174-84
Krasne, F B; Lee, S C (1988) Response-dedicated trigger neurons as control points for behavioral actions: selective inhibition of lateral giant command neurons during feeding in crayfish. J Neurosci 8:3703-12
Krasne, F B (1987) Silencing normal input permits regenerating foreign afferents to innervate an identified crayfish sensory interneuron. J Neurobiol 18:61-73
Miller, M W; Lee, S C; Krasne, F B (1987) Cooperativity-dependent long-lasting potentiation in the crayfish lateral giant escape reaction circuit. J Neurosci 7:1081-92
Glanzman, D L; Krasne, F B (1986) 5,7-Dihydroxytryptamine lesions of crayfish serotonin-containing neurons: effect on the lateral giant escape reaction. J Neurosci 6:1560-9
Krasne, F B; Glanzman, D L (1986) Sensitization of the crayfish lateral giant escape reaction. J Neurosci 6:1013-20

Showing the most recent 10 out of 11 publications