We plan to investigate the neural interactions generating voluntary muscle activity in primates. In monkeys trained to perform isometric force tasks, we will analyze activity of cells with confirmed linkages to wrist and finger muscles. Corticomotoneuronal (CM) cells will be identified by post-spike facilitation of their target muscles in spike-triggered averages of EMG activity. Single motor units, identified by their twitch tension, recruitment threshold and firing pattern will be recorded in the target muscles and cross-correlated with CM cells. We will determine whether CM cells affect all motor units of a muscle or only specific types, and quantify their interaction. Similarly, we will record activity of single Ia afferent fibers in cervical dorsal root ganglia and document their correlational linkages with muscles. Comparing the response patterns of Ia afferents and CM cells during specific active and passive movements will elucidate the role of central vs peripheral pathways impinging on motoneurons. Interactions between CM cells and neighboring cortical cells will also be investigated by cross-correlating their activity during active and passive wrist movements. This will elucidate the intrinsic cortical mechanisms generating controlled muscle activity. Synaptic interactions between motor cortex cells will be further analyzed by intracellular recordings in anesthetized monkeys. Spike-triggered averages would reveal unitary post-synaptic potentials (PSP's) in pyramidal tract neurons produced by identified neighboring cells. The mechanisms underlying transduction of PSP's into changes in firing probability will also be examined for motor cortex cells, and investigated with a computer model. A threshold-crossing model that has simulated empirical observations in motoneurons will be used to study the influence of synaptic noise and PSP parameters on the transform between PSP and cross-correlograms, for both motoneurons and cortical cells.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS012542-15
Application #
3394896
Study Section
Neurology B Subcommittee 1 (NEUB)
Project Start
1978-09-30
Project End
1993-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
15
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Zanos, Stavros; Rembado, Irene; Chen, Daofen et al. (2018) Phase-Locked Stimulation during Cortical Beta Oscillations Produces Bidirectional Synaptic Plasticity in Awake Monkeys. Curr Biol 28:2515-2526.e4
Clausen, Jens; Fetz, Eberhard; Donoghue, John et al. (2017) Help, hope, and hype: Ethical dimensions of neuroprosthetics. Science 356:1338-1339
Lajoie, Guillaume; Krouchev, Nedialko I; Kalaska, John F et al. (2017) Correlation-based model of artificially induced plasticity in motor cortex by a bidirectional brain-computer interface. PLoS Comput Biol 13:e1005343
Eaton, Ryan W; Libey, Tyler; Fetz, Eberhard E (2017) Operant conditioning of neural activity in freely behaving monkeys with intracranial reinforcement. J Neurophysiol 117:1112-1125
Seeman, Stephanie C; Mogen, Brian J; Fetz, Eberhard E et al. (2017) Paired Stimulation for Spike-Timing-Dependent Plasticity in Primate Sensorimotor Cortex. J Neurosci 37:1935-1949
Rembado, Irene; Zanos, Stavros; Fetz, Eberhard E (2017) Cycle-Triggered Cortical Stimulation during Slow Wave Sleep Facilitates Learning a BMI Task: A Case Report in a Non-Human Primate. Front Behav Neurosci 11:59
Smith, William A; Mogen, Brian J; Fetz, Eberhard E et al. (2016) Exploiting Electrocorticographic Spectral Characteristics for Optimized Signal Chain Design: A 1.08 Analog Front End With Reduced ADC Resolution Requirements. IEEE Trans Biomed Circuits Syst 10:1171-1180
Wander, Jeremiah D; Sarma, Devapratim; Johnson, Lise A et al. (2016) Cortico-Cortical Interactions during Acquisition and Use of a Neuroprosthetic Skill. PLoS Comput Biol 12:e1004931
Weaver, Kurt E; Wander, Jeremiah D; Ko, Andrew L et al. (2016) Directional patterns of cross frequency phase and amplitude coupling within the resting state mimic patterns of fMRI functional connectivity. Neuroimage 128:238-251
Moorjani, Samira (2016) Erratum: Addendum: Miniaturized Technologies for Enhancement of Motor Plasticity. Front Bioeng Biotechnol 4:51

Showing the most recent 10 out of 83 publications