Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS012674-21
Application #
2262471
Study Section
Pathology A Study Section (PTHA)
Project Start
1978-12-01
Project End
1999-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Surgery
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Kipkorir, Terry; Colangelo, Christopher M; Manuelidis, Laura (2015) Proteomic analysis of host brain components that bind to infectious particles in Creutzfeldt-Jakob disease. Proteomics 15:2983-98
Botsios, Sotirios; Tittman, Sarah; Manuelidis, Laura (2015) Rapid chemical decontamination of infectious CJD and scrapie particles parallels treatments known to disrupt microbes and biofilms. Virulence 6:787-801
Miyazawa, Kohtaro; Emmerling, Kaitlin; Manuelidis, Laura (2011) High CJD infectivity remains after prion protein is destroyed. J Cell Biochem 112:3630-7
Miyazawa, Kohtaro; Emmerling, Kaitlin; Manuelidis, Laura (2010) Proliferative arrest of neural cells induces prion protein synthesis, nanotube formation, and cell-to-cell contacts. J Cell Biochem 111:239-47
Miyazawa, Kohtaro; Manuelidis, Laura (2010) Agent-specific Shadoo responses in transmissible encephalopathies. J Neuroimmune Pharmacol 5:155-63
Manuelidis, Laura; Liu, Ying; Mullins, Brian (2009) Strain-specific viral properties of variant Creutzfeldt-Jakob disease (vCJD) are encoded by the agent and not by host prion protein. J Cell Biochem 106:220-31
Liu, Ying; Sun, Ru; Chakrabarty, Trisha et al. (2008) A rapid accurate culture assay for infectivity in Transmissible Encephalopathies. J Neurovirol 14:352-61
Manuelidis, Laura; Yu, Zhoa-Xue; Banquero, Nuria et al. (2007) Cells infected with scrapie and Creutzfeldt-Jakob disease agents produce intracellular 25-nm virus-like particles. Proc Natl Acad Sci U S A 104:1965-70
Nishida, Noriuki; Katamine, Shigeru; Manuelidis, Laura (2005) Reciprocal interference between specific CJD and scrapie agents in neural cell cultures. Science 310:493-6
Lu, Zhi Yun; Baker, Christopher A; Manuelidis, Laura (2004) New molecular markers of early and progressive CJD brain infection. J Cell Biochem 93:644-52

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