Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS014138-15A2
Application #
2262593
Study Section
Physiology Study Section (PHY)
Project Start
1977-12-01
Project End
1999-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Rochester
Department
Pharmacology
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Quinn, C C; Begenisich, T (2001) The influence of surface charges on quaternary ammonium block of shaker K+ channels. J Membr Biol 182:233-43
Thompson, J; Begenisich, T (2001) Affinity and location of an internal K+ ion binding site in shaker K channels. J Gen Physiol 117:373-84
Thompson, J; Begenisich, T (2000) Electrostatic interaction between charybdotoxin and a tetrameric mutant of Shaker K(+) channels. Biophys J 78:2382-91
Thompson, J; Begenisich, T (2000) Interaction between quaternary ammonium ions in the pore of potassium channels. Evidence against an electrostatic repulsion mechanism. J Gen Physiol 115:769-82
Perez-Cornejo, P (1999) H+ ion modulation of C-type inactivation of Shaker K+ channels. Pflugers Arch 437:865-70
Perez-Cornejo, P; Stampe, P; Begenisich, T (1998) Proton probing of the charybdotoxin binding site of Shaker K+ channels. J Gen Physiol 111:441-50
Spires, S; Begenisich, T (1995) Voltage-independent gating transitions in squid axon potassium channels. Biophys J 68:491-500
Perez-Cornejo, P; Begenisich, T (1994) The multi-ion nature of the pore in Shaker K+ channels. Biophys J 66:1929-38
Spires, S; Begenisich, T (1994) Modulation of potassium channel gating by external divalent cations. J Gen Physiol 104:675-92
Nealey, T; Spires, S; Eatock, R A et al. (1993) Potassium channels in squid neuron cell bodies: comparison to axonal channels. J Membr Biol 132:13-25

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