Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS014609-17
Application #
2262657
Study Section
Physiology Study Section (PHY)
Project Start
1978-09-15
Project End
2001-02-28
Budget Start
1996-04-01
Budget End
1997-02-28
Support Year
17
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Physiology
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Dong, Tobias X; Othy, Shivashankar; Jairaman, Amit et al. (2017) T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse. Elife 6:
Dong, Tobias X; Othy, Shivashankar; Greenberg, Milton L et al. (2017) Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility. Elife 6:
Dynes, Joseph L; Amcheslavsky, Anna; Cahalan, Michael D (2016) Genetically targeted single-channel optical recording reveals multiple Orai1 gating states and oscillations in calcium influx. Proc Natl Acad Sci U S A 113:440-5
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Perni, Stefano; Dynes, Joseph L; Yeromin, Andriy V et al. (2015) Nanoscale patterning of STIM1 and Orai1 during store-operated Ca2+ entry. Proc Natl Acad Sci U S A 112:E5533-42
Amcheslavsky, Anna; Safrina, Olga; Cahalan, Michael D (2014) State-dependent block of Orai3 TM1 and TM3 cysteine mutants: insights into 2-APB activation. J Gen Physiol 143:621-31
Amcheslavsky, Anna; Safrina, Olga; Cahalan, Michael D (2013) Orai3 TM3 point mutation G158C alters kinetics of 2-APB-induced gating by disulfide bridge formation with TM2 C101. J Gen Physiol 142:405-12
Greenberg, Milton L; Yu, Ying; Leverrier, Sabrina et al. (2013) Orai1 function is essential for T cell homing to lymph nodes. J Immunol 190:3197-206
Khadra, Nadine; Bresson-Bepoldin, Laurence; Penna, Aubin et al. (2011) CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) ?2, and prevents death-inducing signaling complex formation. Proc Natl Acad Sci U S A 108:19072-7

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