Abstract

We propose to systematically study the movement relations of cells throughout the RF in unrestrained cats: 1) Visual and polygraphic observations will be employed to determine the movement relations of RF units during spontaneous behaviors and during systematic behavioral manipulation. Units will be monitored during sleep-waking cycles to determine if any group of RF cells discharges selectively in REM sleep and could therefore have an """"""""executive"""""""" role in its control. 2) Photographic techniques will be used to describe the temporal relationship between unit discharge and movement, and determine the precise topography of movements related to unit activity. 3) Recording of EMG activity will be used to determine if the different classes of RF units are related to activity in recorded muscles and to investigate the pattern of unit-muscle relationships. These studies will lead to a better understanding of the functional roles of RF units. Systematic study and mapping of this brainstem motor control system should contribute to comprehension of its role in both normal behavior and in motor system pathology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS014610-06
Application #
3395666
Study Section
Biopsychology Study Section (BPO)
Project Start
1983-02-01
Project End
1987-01-31
Budget Start
1985-02-01
Budget End
1987-01-31
Support Year
6
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Hospitals
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Shan, Ling; Dauvilliers, Yves; Siegel, Jerome M (2015) Interactions of the histamine and hypocretin systems in CNS disorders. Nat Rev Neurol 11:401-13
Ramanathan, Lalini; Siegel, Jerome M (2014) Gender differences between hypocretin/orexin knockout and wild type mice: age, body weight, body composition, metabolic markers, leptin and insulin resistance. J Neurochem 131:615-24
John, Joshi; Kodama, Tohru; Siegel, Jerome M (2014) Caffeine promotes glutamate and histamine release in the posterior hypothalamus. Am J Physiol Regul Integr Comp Physiol 307:R704-10
Hsieh, Kung-Chiao; Nguyen, Darian; Siegel, Jerome M et al. (2013) New pathways and data on rapid eye movement sleep behaviour disorder in a rat model. Sleep Med 14:719-28
Blouin, Ashley M; Fried, Itzhak; Wilson, Charles L et al. (2013) Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction. Nat Commun 4:1547
John, Joshi; Thannickal, Thomas C; McGregor, Ronald et al. (2013) Greatly increased numbers of histamine cells in human narcolepsy with cataplexy. Ann Neurol 74:786-93
Scammell, T E; Matheson, J K; Honda, M et al. (2012) Coexistence of narcolepsy and Alzheimer's disease. Neurobiol Aging 33:1318-9
Siegel, Jerome M (2011) REM sleep: a biological and psychological paradox. Sleep Med Rev 15:139-42
McGregor, Ronald; Wu, Ming-Fung; Barber, Grace et al. (2011) Highly specific role of hypocretin (orexin) neurons: differential activation as a function of diurnal phase, operant reinforcement versus operant avoidance and light level. J Neurosci 31:15455-67
Wu, Ming-Fung; Nienhuis, Robert; Maidment, Nigel et al. (2011) Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy. J Neurosci 31:6305-10

Showing the most recent 10 out of 85 publications