Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS017360-12S1
Application #
3397506
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1981-07-01
Project End
1994-06-30
Budget Start
1993-02-01
Budget End
1993-06-30
Support Year
12
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Type
Schools of Medicine
DUNS #
622146454
City
Piscataway
State
NJ
Country
United States
Zip Code
08854
Zeevalk, G D; Bernard, L P; Nicklas, W J (2000) Oxidative stress during energy impairment in mesencephalic cultures is not a downstream consequence of a secondary excitotoxicity. Neuroscience 96:309-16
Zeevalk, G D; Bernard, L P; Sinha, C et al. (1998) Excitotoxicity and oxidative stress during inhibition of energy metabolism. Dev Neurosci 20:444-53
Zeevalk, G D; Bernard, L P; Nicklas, W J (1998) Role of oxidative stress and the glutathione system in loss of dopamine neurons due to impairment of energy metabolism. J Neurochem 70:1421-30
Zeevalk, G D; Davis, N; Hyndman, A G et al. (1998) Origins of the extracellular glutamate released during total metabolic blockade in the immature retina. J Neurochem 71:2373-81
Zeevalk, G D; Bernard, L P; Albers, D S et al. (1997) Energy stress-induced dopamine loss in glutathione peroxidase-overexpressing transgenic mice and in glutathione-depleted mesencephalic cultures. J Neurochem 68:426-9
Zeevalk, G D; Nicklas, W J (1996) Hypothermia and metabolic stress: narrowing the cellular site of early neuroprotection. J Pharmacol Exp Ther 279:332-9
Zeevalk, G D; Derr-Yellin, E; Nicklas, W J (1995) Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade. J Pharmacol Exp Ther 275:1124-30
Zeevalk, G D; Schoepp, D; Nicklas, W J (1995) Excitotoxicity at both NMDA and non-NMDA glutamate receptors is antagonized by aurintricarboxylic acid: evidence for differing mechanisms of action. J Neurochem 64:1749-58
Zeevalk, G D; Derr-Yellin, E; Nicklas, W J (1995) NMDA receptor involvement in toxicity to dopamine neurons in vitro caused by the succinate dehydrogenase inhibitor 3-nitropropionic acid. J Neurochem 64:455-8
Zeevalk, G D; Nicklas, W J (1994) Nitric oxide in retina: relation to excitatory amino acids and excitotoxicity. Exp Eye Res 58:343-50

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