Abstract

All nervous systems contain large numbers of different neurotransmitters and neuromodulators. One goal of the proposed research is to test a model that suggests that many of these different substances are released by modulatory neurons to differently configure neural circuits, so that they can produce a number of different outputs. The stomatogastric system of decapod crustaceans will be used as a model preparation. Immunocytochemical and biochemical techniques will be used to identify additional neuropeptides present in the nervous system. Electrophysiological techniques will be used to study the effects of these peptides when exogenously applied to the stomatogastric ganglion. The synaptic contacts made by identified peptidergic modulatory neurons will be studied physiologically and anatomically. The motor patterns produced in vivo by the STG will be measured by electromyography, and compared to the motor patterns produced by the isolated stomatogastric nervous system. The data generated in these studies will provide basic understandings of the mechanisms underlying the generation of rhythmic motor patterns and their modulation by inputs from the central nervous system.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS017813-07
Application #
3397859
Study Section
Neurology B Subcommittee 1 (NEUB)
Project Start
1981-12-01
Project End
1994-11-30
Budget Start
1987-12-01
Budget End
1988-11-30
Support Year
7
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Brandeis University
Department
Type
Schools of Arts and Sciences
DUNS #
616845814
City
Waltham
State
MA
Country
United States
Zip Code
02454

  Publications

Rosenbaum, Philipp; Marder, Eve (2018) Graded Transmission without Action Potentials Sustains Rhythmic Activity in Some But Not All Modulators That Activate the Same Current. J Neurosci 38:8976-8988
Nusbaum, Michael P; Blitz, Dawn M; Marder, Eve (2017) Functional consequences of neuropeptide and small-molecule co-transmission. Nat Rev Neurosci 18:389-403
Marder, Eve; Gutierrez, Gabrielle J; Nusbaum, Michael P (2017) Complicating connectomes: Electrical coupling creates parallel pathways and degenerate circuit mechanisms. Dev Neurobiol 77:597-609
Gjorgjieva, Julijana; Drion, Guillaume; Marder, Eve (2016) Computational implications of biophysical diversity and multiple timescales in neurons and synapses for circuit performance. Curr Opin Neurobiol 37:44-52
Marder, Eve (2015) Understanding brains: details, intuition, and big data. PLoS Biol 13:e1002147
Marder, Eve; Goeritz, Marie L; Otopalik, Adriane G (2015) Robust circuit rhythms in small circuits arise from variable circuit components and mechanisms. Curr Opin Neurobiol 31:156-63
Gutierrez, Gabrielle J; Marder, Eve (2014) Modulation of a Single Neuron Has State-Dependent Actions on Circuit Dynamics(,.) eNeuro 1:
Shruti, Sonal; Schulz, David J; Lett, Kawasi M et al. (2014) Electrical coupling and innexin expression in the stomatogastric ganglion of the crab Cancer borealis. J Neurophysiol 112:2946-58
Hamood, Albert W; Marder, Eve (2014) Animal-to-Animal Variability in Neuromodulation and Circuit Function. Cold Spring Harb Symp Quant Biol 79:21-8
Marder, Eve; O'Leary, Timothy; Shruti, Sonal (2014) Neuromodulation of circuits with variable parameters: single neurons and small circuits reveal principles of state-dependent and robust neuromodulation. Annu Rev Neurosci 37:329-46

Showing the most recent 10 out of 107 publications