Abstract

Susceptibility to many autoimmune diseases is linked to the immune response genes (IR genes), found either in the I region of the murine major histocompatibility comples (H-2) or in the HLA region of the human major histocompatibility complex. This relationship between disease susceptibility and IR genes has been exploited to develop a novel immunosuppressive therapy for models of autoimmune disease including acute and chronic relapsing experimental allergic encephalomyelitis (EAE), experimental autoimmune myasthenia gravis (EAMG), NZB/W F1 lupus-nephritis, experimental autoimmune thyroiditis, streptozocin induced diabetes mellitus, and collagen induced arthritis. In EAE anti I-A antibodies can reverse ongoing paralytic disease. The mechanism whereby anti I-A suppresses EAE will be studied using T cell clones reactive to myelin basic protein that induce EAE. In addition, the effect of anti I-A on the general cellular and humoral status of the recipient will be examined. Finally, the role of IR gene products in the antigen specific suppression of EAE with myelin basic protein-spleen cell conjugates will be examined.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS018235-06
Application #
3398284
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1982-04-01
Project End
1988-03-31
Budget Start
1987-04-01
Budget End
1988-03-31
Support Year
6
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Kanter, Jennifer L; Narayana, Sirisha; Ho, Peggy P et al. (2006) Lipid microarrays identify key mediators of autoimmune brain inflammation. Nat Med 12:138-43
Fontoura, Paulo; Ho, Peggy P; DeVoss, Jason et al. (2004) Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis. J Immunol 173:6981-92
Robinson, William H; Utz, Paul J; Steinman, Lawrence (2003) Genomic and proteomic analysis of multiple sclerosis. Opinion. Curr Opin Immunol 15:660-7
Robinson, William H; Fontoura, Paulo; Lee, Byung J et al. (2003) Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nat Biotechnol 21:1033-9
Neuman de Vegvar, Henry E; Amara, Rama Rao; Steinman, Lawrence et al. (2003) Microarray profiling of antibody responses against simian-human immunodeficiency virus: postchallenge convergence of reactivities independent of host histocompatibility type and vaccine regimen. J Virol 77:11125-38
Pedotti, Rosetta; Sanna, Maija; Tsai, Mindy et al. (2003) Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus. BMC Immunol 4:2
Hueber, Wolfgang; Utz, Paul J; Steinman, Lawrence et al. (2002) Autoantibody profiling for the study and treatment of autoimmune disease. Arthritis Res 4:290-5
Robinson, William H; Steinman, Lawrence; Utz, Paul J (2002) Proteomics technologies for the study of autoimmune disease. Arthritis Rheum 46:885-93
Robinson, William H; DiGennaro, Carla; Hueber, Wolfgang et al. (2002) Autoantigen microarrays for multiplex characterization of autoantibody responses. Nat Med 8:295-301
Robinson, William H; Steinman, Lawrence; Utz, Paul J (2002) Protein and peptide array analysis of autoimmune disease. Biotechniques Suppl:66-9

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