The long term objective of this work is to define the role of the cerebellar cortex in motor behavior. The first goal is to describe the kinematic parameters represented in both the simple and complex spike discharge of Purkinje cells during multi-joint, two dimensional, visually guided arm movements in the primate. In different areas of the cerebellum, the """"""""movement fields"""""""" of Purkinje cells will be determined for movements of different distances and directions throughout the horizontal plane. Whether the responses are defined in a head/body or hand centered reference frame will be evaluated. The correlation of the simple and complex spike response with the movement kinematics and electromyographic activity will be determined. The second series of studies will evaluate the role of cerebellar Purkinje cells in the feedforward and feedback control of visually guided limb movement. Introduction of visual feedback errors during the arm movement in primates will permit introduction of quantitative errors into the movement. In these experiments the discharge of Purkinje cells and its correlation with either the movement parameters or the errors introduced into the visual feedback loop will be determined. The cerebellum has been hypothesized to play a significant role in motor learning. Experiments are proposed to evaluate this hypothesis in voluntary, motor learning. In this last set of studies the discharge of Purkinje cells will be evaluated during the motor learning required to compensate for visual feedback disparity during visually guided arm movements. Analysis of the simple and complex spike discharge prior to, during and after learning and the relationship of the discharge to the kinematic changes associated with learning will be determined.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS018338-11
Application #
3398386
Study Section
Neurology A Study Section (NEUA)
Project Start
1982-04-01
Project End
1995-03-31
Budget Start
1992-04-01
Budget End
1993-03-31
Support Year
11
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Hedges, Valerie L; Chen, Gang; Yu, Lei et al. (2018) Local Estrogen Synthesis Regulates Parallel Fiber-Purkinje Cell Neurotransmission Within the Cerebellar Cortex. Endocrinology 159:1328-1338
Streng, Martha L; Popa, Laurentiu S; Ebner, Timothy J (2018) Modulation of sensory prediction error in Purkinje cells during visual feedback manipulations. Nat Commun 9:1099
Streng, Martha L; Popa, Laurentiu S; Ebner, Timothy J (2017) Climbing fibers predict movement kinematics and performance errors. J Neurophysiol 118:1888-1902
Streng, Martha L; Popa, Laurentiu S; Ebner, Timothy J (2017) Climbing Fibers Control Purkinje Cell Representations of Behavior. J Neurosci 37:1997-2009
Lang, Eric J; Apps, Richard; Bengtsson, Fredrik et al. (2017) The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper. Cerebellum 16:230-252
Popa, Laurentiu S; Streng, Martha L; Ebner, Timothy J (2017) Long-Term Predictive and Feedback Encoding of Motor Signals in the Simple Spike Discharge of Purkinje Cells. eNeuro 4:
Popa, Laurentiu S; Streng, Martha L; Hewitt, Angela L et al. (2016) The Errors of Our Ways: Understanding Error Representations in Cerebellar-Dependent Motor Learning. Cerebellum 15:93-103
Hewitt, Angela L; Popa, Laurentiu S; Ebner, Timothy J (2015) Changes in Purkinje cell simple spike encoding of reach kinematics during adaption to a mechanical perturbation. J Neurosci 35:1106-24
Cramer, Samuel W; Popa, Laurentiu S; Carter, Russell E et al. (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. J Neurosci 35:5664-79
Prosise, Jodi F; Hendrix, Claudia M; Ebner, Timothy J (2015) Joint angles and angular velocities and relevance of eigenvectors during prehension in the monkey. Exp Brain Res 233:339-50

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