Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS018667-12A1
Application #
2263465
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1983-07-01
Project End
2000-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Tufts University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111
Beinfeld, Margery C (2003) Biosynthesis and processing of pro CCK: recent progress and future challenges. Life Sci 72:747-57
Cain, Brian M; Vishnuvardhan, Daesety; Wang, Wenge et al. (2002) Production, purification, and characterization of recombinant prohormone convertase 5 from baculovirus-infected insect cells. Protein Expr Purif 24:227-33
Vishnuvardhan, Daesety; Beinfeld, Margery C (2002) Biosynthesis and post-translational processing of site-directed endoproteolytic cleavage mutants of Pro-CCK in AtT-20 cells. Biochemistry 41:570-8
Beinfeld, M C; Connolly, K (2001) Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibits potassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial memory defects produced by cannabinoids. Neurosci Lett 301:69-71
Beinfeld, M C; Connolly, K; Pierce, R C (2001) OLETF (Otsuka Long-Evans Tokushima Fatty) rats that lack the CCK 1 (A) receptor develop less behavioral sensitization to repeated cocaine treatment than wild type LETO (Long Evans Tokushima Otsuka) rats. Peptides 22:1285-90
Vishnuvardhan, D; Beinfeld, M C (2000) Role of tyrosine sulfation and serine phosphorylation in the processing of procholecystokinin to amidated cholecystokinin and its secretion in transfected AtT-20 cells. Biochemistry 39:13825-30
Vishnuvardhan, D; Beinfeld, M C (2000) Lovastatin is a potent inhibitor of cholecystokinin secretion in endocrine tumor cells in culture. Peptides 21:553-7
Wang, W; Birch, N P; Beinfeld, M C (1998) Prohormone convertase 1 (PC1) when expressed with pro cholecystokinin (pro CCK) in L cells performs three endoproteolytic cleavages which are observed in rat brain and in CCK-expressing endocrine cells in culture, including the production of glycine and a Biochem Biophys Res Commun 248:538-41
Wang, W; Cain, B M; Beinfeld, M C (1998) Adult carboxypeptidase E-deficient fat/fat mice have a near-total depletion of brain CCK 8 accompanied by a massive accumulation of glycine and arginine extended CCK: identification of CCK 8 Gly as the immediate precursor of CCK 8 in rodent brain. Endocrine 9:329-32
Beinfeld, M C; Perloff, M D; Venkatakrishnan, K (1998) Identification of glycine-extended CCK peptides in endocrine cells and modulation of CCK amide and CCK Gly content and secretion from endocrine tumor cells by an inhibitor of amidation. Peptides 19:1393-8

Showing the most recent 10 out of 61 publications