Abstract

This project aims to map the distribution of chemically specified Purkinje cells in the rat's cerebellar cortex and to correlate their pattern with the parasagittal zones of identified afferents to the cerebellar cortex. Immunocytochemical methods will be used to identify and trace the afferent systems. Electron microscopy will be used to correlate the microzones of chemically specific Purkinje cells with afferents of particular origins. These studies open a new field of neuroanatomy in which the cellular architecture of the brain is analyzed in terms of the connections list made by chemically specified neurons. The cerebellar circuits can serve as a model for other parts of the mammalian brain. Since the cerebellulm is an important integrating center for the control of movement, the hereditary cerebellar degenerations, Parkinson's disease, and the cerebellar degenerations associated with chronic alcoholism, thiamine deficiency, and carbon monoxide poisoning.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS019010-03
Application #
3399010
Study Section
Neurology B Subcommittee 1 (NEUB)
Project Start
1983-08-01
Project End
1988-07-31
Budget Start
1985-08-01
Budget End
1988-07-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Yee, W C; Drachman, D B; Walser, M et al. (1988) Effect of ketoleucine treatment on atrophy of skeletal muscle. Exp Neurol 99:1-9
McIntosh, K R; Drachman, D B (1987) Properties of suppressor cells induced to acetylcholine receptor using cyclosporin A. Ann N Y Acad Sci 505:628-38
Drachman, D B; de Silva, S; Ramsay, D et al. (1987) Humoral pathogenesis of myasthenia gravis. Ann N Y Acad Sci 505:90-105
Kohler, C; Radesater, A C; Chan-Palay, V (1987) Distribution of neurotensin receptors in the primate hippocampal region: a quantitative autoradiographic study in the monkey and the postmortem human brain. Neurosci Lett 76:145-50
Drachman, D B (1987) Myasthenia gravis: a model disorder of acetylcholine receptors. Res Publ Assoc Res Nerv Ment Dis 65:65-82
Kohler, C; Eriksson, L G; Davies, S et al. (1987) Co-localization of neuropeptide tyrosine and somatostatin immunoreactivity in neurons of individual subfields of the rat hippocampal region. Neurosci Lett 78:1-6
Chan-Palay, V; Kohler, C; Haesler, U et al. (1986) Distribution of neurons and axons immunoreactive with antisera against neuropeptide Y in the normal human hippocampus. J Comp Neurol 248:360-75
Chan-Palay, V; Lang, W; Haesler, U et al. (1986) Distribution of altered hippocampal neurons and axons immunoreactive with antisera against neuropeptide Y in Alzheimer's-type dementia. J Comp Neurol 248:376-94
Kohler, C; Radesater, A C; Lang, W et al. (1986) Distribution of serotonin-1A receptors in the monkey and the postmortem human hippocampal region. A quantitative autoradiographic study using the selective agonist [3H]8-OH-DPAT. Neurosci Lett 72:43-8
Kohler, C; Ericson, H; Watanabe, T et al. (1986) Galanin immunoreactivity in hypothalamic neurons: further evidence for multiple chemical messengers in the tuberomammillary nucleus. J Comp Neurol 250:58-64

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