This is a request for a five year renewal of an NIH grant focusing on hemispheric specialization and interaction at the interface of language and cognition. A convergent research program is outlined which studies neurological patients and normal subjects and combines behavioral and anatomical methods. Technological developments include a powerful computer-based laboratory for laterality research and an eye-tracker with scotoma simulator for hemispheric ocular scanning without attachments to the eye. Theoretical work will continue on behavioral models of laterality effects and conditions for parallel independent processing in the two hemispheres. One set of experiments will study independent lexical access and organization, syntactic and pragmatic competence and associated cognitive abilities in each of the two hemispheres, including the ability to learn new linguistic material and to monitor and correct errors. In parallel, other experiments will study hemispheric independence in processing and monitoring nonverbal tasks, including visual imagery, visual illusions, face recognition, and object classification. Another set of experiments will analyze individual differences in regional patterns of callosal connectivity using behavioral and anatomical measures, especially in relation to cognitive profile. Biological and environmental conditions that change callosal connectivity will be investigated. Neuropathological sections of the callosum will be compared to MRI measures, and used to count fibers of different types in several regions. Results promise better understanding and possible control of cognitive pathology due to abnormal cerebral activation or faulty interhemispheric communication. The data will contribute to theoretical cognitive neuroscience by understanding how language is organized in the brain and how independent, parallel cortical processing modules interact.
| Mooshagian, Eric; Iacoboni, Marco; Zaidel, Eran (2009) Spatial attention and interhemispheric visuomotor integration in the absence of the corpus callosum. Neuropsychologia 47:933-7 |
| Uddin, Lucina Q; Mooshagian, Eric; Zaidel, Eran et al. (2008) Residual functional connectivity in the split-brain revealed with resting-state functional MRI. Neuroreport 19:703-9 |
| Greene, Deanna J; Barnea, Anat; Herzberg, Kristin et al. (2008) Measuring attention in the hemispheres: the lateralized attention network test (LANT). Brain Cogn 66:21-31 |
| Mooshagian, Eric; Iacoboni, Marco; Zaidel, Eran (2008) The role of task history in simple reaction time to lateralized light flashes. Neuropsychologia 46:659-64 |
| Fernandino, Leonardo; Iacoboni, Marco; Zaidel, Eran (2007) The effects of bilateral presentations on lateralized lexical decision. Brain Cogn 64:60-7 |
| de Bode, Stella; Sininger, Yvonne; Healy, Eric W et al. (2007) Dichotic listening after cerebral hemispherectomy: methodological and theoretical observations. Neuropsychologia 45:2461-6 |
| Hale, T Sigi; Zaidel, Eran; McGough, James J et al. (2006) Atypical brain laterality in adults with ADHD during dichotic listening for emotional intonation and words. Neuropsychologia 44:896-904 |
| Luders, E; Narr, K L; Zaidel, E et al. (2006) Parasagittal asymmetries of the corpus callosum. Cereb Cortex 16:346-54 |
| Aziz-Zadeh, Lisa; Koski, Lisa; Zaidel, Eran et al. (2006) Lateralization of the human mirror neuron system. J Neurosci 26:2964-70 |
| Luders, Eileen; Narr, Katherine L; Zaidel, Eran et al. (2006) Gender effects on callosal thickness in scaled and unscaled space. Neuroreport 17:1103-6 |
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