Stimulation of various brain stem areas can initiate and maintain walking in decerebrate animals through the modulation of spinal pattern generators. The applicants have previously described anatomical, functional and neurochemical organizational components of these areas. Information was provided on the elements required for locomotion including progressive movement, rhythm generation, and postural stability. Single unit recording in mesopontine cholinergic cell groups revealed the classes of neurons involved in stepping. These past studies have led to the development of a device for epidural stimulation of the spinal cord which can induce locomotion and respiration. Hypotheses on the organization and modulation of rhythmic functions by the brain stem were also generated by past findings and have led to the present application. Electrophysiological techniques are to be used to address three mechanisms. 1) How these brain stem areas process sensory afferent information in the modulation of ongoing activity as well as changes in state will be addressed. 2) How cholinergic and catecholaminergic cell groups in the region interact in the modulation of rhythmic functions will be studied. 3) How these cell groups modulate reticulospinal efferent systems will be investigated. These studies may provide information relevant to the modulation of locomotor function, sleep-wake states and arousal.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS020246-09A2
Application #
3400506
Study Section
Special Emphasis Panel (ZRG7-SSS-5 (01))
Project Start
1984-03-01
Project End
1997-06-30
Budget Start
1993-07-01
Budget End
1994-06-30
Support Year
9
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Type
Schools of Medicine
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205
González, Betina; González, Candela; Bisagno, Verónica et al. (2017) EFFECTS OF METHAMPHETAMINE ON LOCOMOTOR ACTIVITY AND THALAMIC GENE EXPRESSION IN LEPTIN-DEFICIENT OBESE MICE. Transl Brain Rhythm 2:
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D'Onofrio, Stasia; Urbano, Francisco J; Messias, Erick et al. (2016) Lithium decreases the effects of neuronal calcium sensor protein 1 in pedunculopontine neurons. Physiol Rep 4:
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D'Onofrio, Stasia; Kezunovic, Nebojsa; Hyde, James R et al. (2015) Modulation of gamma oscillations in the pedunculopontine nucleus by neuronal calcium sensor protein-1: relevance to schizophrenia and bipolar disorder. J Neurophysiol 113:709-19
Garcia-Rill, Edgar; Luster, Brennon; D'Onofrio, Stasia et al. (2015) Pedunculopontine arousal system physiology - Deep brain stimulation (DBS). Sleep Sci 8:153-61
Garcia-Rill, Edgar; Luster, Brennon; Mahaffey, Susan et al. (2015) Pedunculopontine Gamma Band Activity and Development. Brain Sci 5:546-67

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