We have transferred the grant to the Neurosciences Institute at the Hospital for the Good Samaritan which has heavily supported our research resulting in larger patient volume and higher productivity. We will complete the major goals of the grant within the time awarded on the grant. The 7 channel magnetometer, shielded room, and PPI are working well in our new larger laboratory with coregistration of MEG, EEG, ECoG, and MRI data with 1mm resolution, excellent signal-to-noise ratios for spikes and seizures, and adequate spatial coverage of the coplanar MEG array to capture a phase reversal and null point of spontaneous seizures and spikes during simultaneous 128 channel ECoG. We have studied a large number of events in more patients and plan to study large populations. We have determined that a comprehensive study of each patient improves localization accuracy and comparisons and that larger patient sample size is necessary to test our hypotheses. We will extend research in each step of the 5 step approach. We propose to study a larger number of patients with complete studies of MEG, EEG, and ECoG for implanted dipoles, evoked responses, and spontaneous spikes and spontaneous and induced seizures in each patient. We want to investigate propagation patterns of spikes and seizures for more accurate quantification of epileptic areas, of potential importance for surgical treatment. We will continue to compare 7 MEG + 128 EEG channels to 37 MEG + 128 EEG channels to determine the added value of a large array MEG system. We believe the combination of 7 MEG and 60 EEG channels can answer important questions similar to a larger array MEG system. We will use and improve multiple fixed dipole solutions in MEG, EEG, and ECoG with MR information in individual patients, an EEG 4 shell model with measurements of conductivities in individual patients, our finite element model, localizations of digit rostrocaudal bands and the different cortices of posterior tibial nerve , and localizations of spontaneous and induced partial seizures in simultaneous MEG+EEG and MEG+ECoG. We will make a detailed comparison of spatiotemporal structure from multiple source modeling between the better understood evoked response and the less understood spike and seizure.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS020806-15
Application #
2677086
Study Section
Special Emphasis Panel (ZRG1-NEUB-2 (01))
Program Officer
Jacobs, Margaret
Project Start
1993-05-01
Project End
2000-02-29
Budget Start
1997-12-01
Budget End
2000-02-29
Support Year
15
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Huntington Medical Research Institutes
Department
Type
DUNS #
077978898
City
Pasadena
State
CA
Country
United States
Zip Code
91101
Sutherling, W W; Mamelak, A N; Thyerlei, D et al. (2008) Influence of magnetic source imaging for planning intracranial EEG in epilepsy. Neurology 71:990-6
Merrifield, Warren S; Simos, Panagiotis G; Papanicolaou, Andrew C et al. (2007) Hemispheric language dominance in magnetoencephalography: sensitivity, specificity, and data reduction techniques. Epilepsy Behav 10:120-8
Merrifield, Warren S; Sutherling, William W; Mamelak, Adam N (2007) Statistical parameters of epileptiform brain activity differentiate frontal and temporal lobe patients. Epilepsy Res 74:74-8
Wu, J Y; Sutherling, W W; Koh, S et al. (2006) Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex. Neurology 66:1270-2
Ossadtchi, A; Mosher, J C; Sutherling, W W et al. (2005) Hidden Markov modelling of spike propagation from interictal MEG data. Phys Med Biol 50:3447-69
Ossadtchi, A; Baillet, S; Mosher, J C et al. (2004) Automated interictal spike detection and source localization in magnetoencephalography using independent components analysis and spatio-temporal clustering. Clin Neurophysiol 115:508-22
Mamelak, Adam N; Lopez, Nancy; Akhtari, Massoud et al. (2002) Magnetoencephalography-directed surgery in patients with neocortical epilepsy. J Neurosurg 97:865-73
Akhtari, M; Bryant, H C; Mamelak, A N et al. (2002) Conductivities of three-layer live human skull. Brain Topogr 14:151-67
Sutherling, W W; Akhtari, M; Mamelak, A N et al. (2001) Dipole localization of human induced focal afterdischarge seizure in simultaneous magnetoencephalography and electrocorticography. Brain Topogr 14:101-16
Akhtari, M; Bryant, H C; Mamelak, A N et al. (2000) Conductivities of three-layer human skull. Brain Topogr 13:29-42

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