Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS020904-11S1
Application #
3401559
Study Section
Virology Study Section (VR)
Project Start
1984-07-01
Project End
1995-06-30
Budget Start
1991-07-15
Budget End
1992-06-30
Support Year
11
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Pekosz, A; Gonzalez-Scarano, F (1996) The extracellular domain of La Crosse virus G1 forms oligomers and undergoes pH-dependent conformational changes. Virology 225:243-7
Bupp, K; Stillmock, K; Gonzalez-Scarano, F (1996) Analysis of the intracellular transport properties of recombinant La Crosse virus glycoproteins. Virology 220:485-90
Pekosz, A; Phillips, J; Pleasure, D et al. (1996) Induction of apoptosis by La Crosse virus infection and role of neuronal differentiation and human bcl-2 expression in its prevention. J Virol 70:5329-35
Roberts, A; Rossier, C; Kolakofsky, D et al. (1995) Completion of the La Crosse virus genome sequence and genetic comparisons of the L proteins of the Bunyaviridae. Virology 206:742-5
Pekosz, A; Griot, C; Stillmock, K et al. (1995) Protection from La Crosse virus encephalitis with recombinant glycoproteins: role of neutralizing anti-G1 antibodies. J Virol 69:3475-81
Pekosz, A; Griot, C; Nathanson, N et al. (1995) Tropism of bunyaviruses: evidence for a G1 glycoprotein-mediated entry pathway common to the California serogroup. Virology 214:339-48
Griot, C; Pekosz, A; Davidson, R et al. (1994) Replication in cultured C2C12 muscle cells correlates with the neuroinvasiveness of California serogroup bunyaviruses. Virology 201:399-403
Griot, C; Gonzalez-Scarano, F; Nathanson, N (1993) Molecular determinants of the virulence and infectivity of California serogroup bunyaviruses. Annu Rev Microbiol 47:117-38
Jacoby, D R; Cooke, C; Prabakaran, I et al. (1993) Expression of the La Crosse M segment proteins in a recombinant vaccinia expression system mediates pH-dependent cellular fusion. Virology 193:993-6
Griot, C; Pekosz, A; Lukac, D et al. (1993) Polygenic control of neuroinvasiveness in California serogroup bunyaviruses. J Virol 67:3861-7

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