Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS021458-07S1
Application #
3402576
Study Section
Neurology A Study Section (NEUA)
Project Start
1985-07-01
Project End
1992-04-06
Budget Start
1991-09-19
Budget End
1992-04-06
Support Year
7
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Virginia Commonwealth University
Department
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298

  Publications

Zhao, X; Bausano, B; Pike, B R et al. (2001) TNF-alpha stimulates caspase-3 activation and apoptotic cell death in primary septo-hippocampal cultures. J Neurosci Res 64:121-31
Newcomb, J K; Pike, B R; Zhao, X et al. (2000) Concurrent assessment of calpain and caspase-3 activity by means of western blots of protease-specific spectrin breakdown products. Methods Mol Biol 144:219-23
Pike, B R; Zhao, X; Newcomb, J K et al. (2000) Stretch injury causes calpain and caspase-3 activation and necrotic and apoptotic cell death in septo-hippocampal cell cultures. J Neurotrauma 17:283-98
Zhao, X; Newcomb, J K; Pike, B R et al. (2000) Novel characteristics of glutamate-induced cell death in primary septohippocampal cultures: relationship to calpain and caspase-3 protease activation. J Cereb Blood Flow Metab 20:550-62
Posmantur, R M; Newcomb, J K; Kampfl, A et al. (2000) Light and confocal microscopic studies of evolutionary changes in neurofilament proteins following cortical impact injury in the rat. Exp Neurol 161:15-26
Zou, L L; Huang, L; Hayes, R L et al. (1999) Liposome-mediated NGF gene transfection following neuronal injury: potential therapeutic applications. Gene Ther 6:994-1005
Zhao, X; Pike, B R; Newcomb, J K et al. (1999) Maitotoxin induces calpain but not caspase-3 activation and necrotic cell death in primary septo-hippocampal cultures. Neurochem Res 24:371-82
Newcomb, J K; Zhao, X; Pike, B R et al. (1999) Temporal profile of apoptotic-like changes in neurons and astrocytes following controlled cortical impact injury in the rat. Exp Neurol 158:76-88
Newcomb, J K; Pike, B R; Zhao, X et al. (1999) Altered calpastatin protein levels following traumatic brain injury in rat. J Neurotrauma 16:1-11
Pike, B R; Zhao, X; Newcomb, J K et al. (1998) Temporal relationships between de novo protein synthesis, calpain and caspase 3-like protease activation, and DNA fragmentation during apoptosis in septo-hippocampal cultures. J Neurosci Res 52:505-20

Showing the most recent 10 out of 87 publications