Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS021716-11
Application #
2264259
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1988-03-01
Project End
1997-03-31
Budget Start
1995-08-01
Budget End
1997-03-31
Support Year
11
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Worcester Foundation for Biomedical Research
Department
Type
DUNS #
City
Shrewsbury
State
MA
Country
United States
Zip Code
01545
Weatherbee, Jessica L; Kraus, Jean-Louis; Ross, Alonzo H (2016) ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis. Oncotarget 7:43820-43834
Heinrich, Frank; Chakravarthy, Srinivas; Nanda, Hirsh et al. (2015) The PTEN Tumor Suppressor Forms Homodimers in Solution. Structure 23:1952-1957
Harishchandra, Rakesh K; Neumann, Brittany M; Gericke, Arne et al. (2015) Biophysical methods for the characterization of PTEN/lipid bilayer interactions. Methods 77-78:125-35
Ramirez, Yulian P; Mladek, Ann C; Phillips, Roger M et al. (2015) Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth. Mol Cancer Ther 14:111-9
Karpel-Massler, Georg; Shu, Chang; Chau, Lily et al. (2015) Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo. Oncotarget 6:14507-21
Pareja, Fresia; Macleod, David; Shu, Chang et al. (2014) PI3K and Bcl-2 inhibition primes glioblastoma cells to apoptosis through downregulation of Mcl-1 and Phospho-BAD. Mol Cancer Res 12:987-1001
Jiang, Zhiping; Redfern, Roberta E; Isler, Yasmin et al. (2014) Cholesterol stabilizes fluid phosphoinositide domains. Chem Phys Lipids 182:52-61
Ramirez, Yulian P; Weatherbee, Jessica L; Wheelhouse, Richard T et al. (2013) Glioblastoma multiforme therapy and mechanisms of resistance. Pharmaceuticals (Basel) 6:1475-506
Gericke, Arne; Leslie, Nicholas R; Lösche, Mathias et al. (2013) PtdIns(4,5)P2-mediated cell signaling: emerging principles and PTEN as a paradigm for regulatory mechanism. Adv Exp Med Biol 991:85-104
Shenoy, Siddharth; Shekhar, Prabhanshu; Heinrich, Frank et al. (2012) Membrane association of the PTEN tumor suppressor: molecular details of the protein-membrane complex from SPR binding studies and neutron reflection. PLoS One 7:e32591

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