Our plan of research includes (1) continued accrual of children and adolescents hospitalized following nonmissile head injury; (2) follow-up of both the new admissions and children whom we have already examined at baseline until 24 months after injury; (3) publication of our study concerning the presence and persistence of memory deficit in children and adolescents in relation to the severity of injury and the lateralization and localization of lesion as assessed by computed tomographic (CT) and surgical findings; (4) completion of a study concerning early predictors of long term cognitive impairment in relation to the age at injury and indices oif the severity of subacute cerebral insult; (5) comparison of long term effects of head injury sustained during infancy as compared to the outcome of a similar injury in adults; (6) publication of preliminary findings concerning the relationship between the neuropathologic findings provided by magnetic resonsance imaging in long term survivors of severe closed head injury and neurobehavioral sequelae.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS021889-05
Application #
3403583
Study Section
Human Development and Aging Subcommittee 1 (HUD)
Project Start
1984-07-01
Project End
1991-06-30
Budget Start
1988-07-01
Budget End
1989-06-30
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Max, Jeffrey E; Friedman, Keren; Wilde, Elisabeth A et al. (2015) Psychiatric disorders in children and adolescents 24 months after mild traumatic brain injury. J Neuropsychiatry Clin Neurosci 27:112-20
Max, Jeffrey E; Lopez, Aholibama; Wilde, Elisabeth A et al. (2015) Anxiety disorders in children and adolescents in the second six months after traumatic brain injury. J Pediatr Rehabil Med 8:345-55
Max, Jeffrey E; Wilde, Elisabeth A; Bigler, Erin D et al. (2015) Personality Change Due to Traumatic Brain Injury in Children and Adolescents: Neurocognitive Correlates. J Neuropsychiatry Clin Neurosci 27:272-9
Rabinowitz, Amanda R; Li, Xiaoqi; Levin, Harvey S (2014) Sport and nonsport etiologies of mild traumatic brain injury: similarities and differences. Annu Rev Psychol 65:301-31
Schmidt, Adam T; Li, Xiaoqi; Zhang-Rutledge, Kathy et al. (2014) A history of low birth weight alters recovery following a future head injury: a case series. Child Neuropsychol 20:495-508
Rabinowitz, Amanda R; Levin, Harvey S (2014) Cognitive sequelae of traumatic brain injury. Psychiatr Clin North Am 37:1-11
Lipszyc, Jonathan; Levin, Harvey; Hanten, Gerri et al. (2014) Frontal white matter damage impairs response inhibition in children following traumatic brain injury. Arch Clin Neuropsychol 29:289-99
Ornstein, Tisha J; Sagar, Sanya; Schachar, Russell J et al. (2014) Neuropsychological performance of youth with secondary attention-deficit/hyperactivity disorder 6- and 12-months after traumatic brain injury. J Int Neuropsychol Soc 20:971-81
Gonzaga-Jauregui, Claudia; Lotze, Timothy; Jamal, Leila et al. (2013) Mutations in VRK1 associated with complex motor and sensory axonal neuropathy plus microcephaly. JAMA Neurol 70:1491-8
Ornstein, Tisha J; Max, Jeffrey E; Schachar, Russell et al. (2013) Response inhibition in children with and without ADHD after traumatic brain injury. J Neuropsychol 7:1-11

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