Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS021913-21
Application #
2264309
Study Section
Special Emphasis Panel (ZRG4-PTHA (01))
Project Start
1984-07-01
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Evanston Hospital
Department
Type
DUNS #
City
Evanston
State
IL
Country
United States
Zip Code
60201
Hertzler, Shannon; Liang, Zhiguo; Treso, Balint et al. (2011) Adaptation of Saffold virus 2 for high-titer growth in mammalian cells. J Virol 85:7411-8
Liang, Zhiguo; Kumar, A S Manoj; Jones, Morris S et al. (2008) Phylogenetic analysis of the species Theilovirus: emerging murine and human pathogens. J Virol 82:11545-54
Lipton, Howard L; Liang, Zhiguo; Hertzler, Shannon et al. (2007) A specific viral cause of multiple sclerosis: one virus, one disease. Ann Neurol 61:514-23
Lipton, Howard L; Kallio, Patricia; Jelachich, Mary Lou (2005) Simplified quantitative analysis of spinal cord cells from Theiler's virus-infected mice without the requirement for myelin debris removal. J Immunol Methods 299:107-15
Reddi, Honey V; Kumar, A S Manoj; Kung, Aisha Y et al. (2004) Heparan sulfate-independent infection attenuates high-neurovirulence GDVII virus-induced encephalitis. J Virol 78:8909-16
Trottier, Mark; Schlitt, Brian P; Kung, Aisha Y et al. (2004) Transition from acute to persistent Theiler's virus infection requires active viral replication that drives proinflammatory cytokine expression and chronic demyelinating disease. J Virol 78:12480-8
Kumar, A S Manoj; Reddi, Honey V; Kung, Aisha Y et al. (2004) Virus persistence in an animal model of multiple sclerosis requires virion attachment to sialic acid coreceptors. J Virol 78:8860-7
Kumar, A S Manoj; Kallio, Patricia; Luo, Ming et al. (2003) Amino acid substitutions in VP2 residues contacting sialic acid in low-neurovirulence BeAn virus dramatically reduce viral binding and spread of infection. J Virol 77:2709-16
Reddi, Honey V; Lipton, Howard L (2002) Heparan sulfate mediates infection of high-neurovirulence Theiler's viruses. J Virol 76:8400-7
Jelachich, M L; Bramlage, C; Lipton, H L (1999) Differentiation of M1 myeloid precursor cells into macrophages results in binding and infection by Theiler's murine encephalomyelitis virus and apoptosis. J Virol 73:3227-35

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