Abstract

The objectives of these experiments are twofold. Firt, studies will be performed to examine mechanisms by which information is processed in the cerebellar cortex. Specifically, the changes in the temporal patterning of Purkinje cell spikes resulting from the activation of cerebellar afferent pathways will be evaluated. Particular emphasis will be placed on determining the extent to which the patterning of simple spikes produced by the action of climbing fibers contributes to the responsiveness of Purkinje cells to mossy fiber inputs. Second, a separate series of studies will examine the action of dentato-bulbospinal pathways on segmental reflexes. The effects of activating this system on the stretch reflex and the cutaneomuscular reflexes will be assessed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS021958-09
Application #
3403729
Study Section
Neurology A Study Section (NEUA)
Project Start
1984-08-01
Project End
1994-07-31
Budget Start
1992-08-01
Budget End
1993-07-31
Support Year
9
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
St. Joseph's Hosp/Medical Center (Phoenix)
Department
Type
DUNS #
City
Phoenix
State
AZ
Country
United States
Zip Code
85013

  Publications

Zbarska, Svitlana; Bloedel, James R; Bracha, Vlastislav (2008) Cerebellar dysfunction explains the extinction-like abolition of conditioned eyeblinks after NBQX injections in the inferior olive. J Neurosci 28:10-20
Zbarska, S; Holland, E A; Bloedel, J R et al. (2007) Inferior olivary inactivation abolishes conditioned eyeblinks: extinction or cerebellar malfunction? Behav Brain Res 178:128-38
Nilaweera, W U; Zenitsky, G D; Bracha, V (2006) Inactivation of cerebellar output axons impairs acquisition of conditioned eyeblinks. Brain Res 1122:143-53
Nilaweera, Wijitha U; Zenitsky, Gary D; Bracha, Vlastislav (2005) Inactivation of the brachium conjunctivum prevents extinction of classically conditioned eyeblinks. Brain Res 1045:175-84
Aksenov, D P; Serdyukova, N A; Bloedel, J R et al. (2005) Glutamate neurotransmission in the cerebellar interposed nuclei: involvement in classically conditioned eyeblinks and neuronal activity. J Neurophysiol 93:44-52
Shimansky, Yury; Wang, Jian-Jun; Bauer, Richard A et al. (2004) On-line compensation for perturbations of a reaching movement is cerebellar dependent: support for the task dependency hypothesis. Exp Brain Res 155:156-72
Aksenov, D; Serdyukova, N; Irwin, K et al. (2004) GABA neurotransmission in the cerebellar interposed nuclei: involvement in classically conditioned eyeblinks and neuronal activity. J Neurophysiol 91:719-27
Bloedel, James R (2004) Task-dependent role of the cerebellum in motor learning. Prog Brain Res 143:319-29
Bracha, Vlastislav (2004) Role of the cerebellum in eyeblink conditioning. Prog Brain Res 143:331-9
Bracha, Vlastislav; Nilaweera, W; Zenitsky, G et al. (2003) Video recording system for the measurement of eyelid movements during classical conditioning of the eyeblink response in the rabbit. J Neurosci Methods 125:173-81

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