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Rubinsztein, David C; Orr, Harry T (2016) Diminishing return for mechanistic therapeutics with neurodegenerative disease duration?: There may be a point in the course of a neurodegenerative condition where therapeutics targeting disease-causing mechanisms are futile. Bioessays 38:977-80
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Nelson, David L; Orr, Harry T; Warren, Stephen T (2013) The unstable repeats--three evolving faces of neurological disease. Neuron 77:825-43
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Ebner, Blake A; Ingram, Melissa A; Barnes, Justin A et al. (2013) Purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum. J Neurosci 33:5806-20
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Orr, Harry T (2012) Cell biology of spinocerebellar ataxia. J Cell Biol 197:167-77
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Ingram, Melissa A C; Orr, Harry T; Clark, H Brent (2012) Genetically engineered mouse models of the trinucleotide-repeat spinocerebellar ataxias. Brain Res Bull 88:33-42
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Orr, Harry T (2012) Polyglutamine neurodegeneration: expanded glutamines enhance native functions. Curr Opin Genet Dev 22:251-5
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Fryer, John D; Yu, Peng; Kang, Hyojin et al. (2011) Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua. Science 334:690-3
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Gehrking, Kristin M; Andresen, J Michael; Duvick, Lisa et al. (2011) Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model. Hum Mol Genet 20:2204-12
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Oz, Gülin; Vollmers, Manda L; Nelson, Christopher D et al. (2011) In vivo monitoring of recovery from neurodegeneration in conditional transgenic SCA1 mice. Exp Neurol 232:290-8
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Barnes, Justin A; Ebner, Blake A; Duvick, Lisa A et al. (2011) Abnormalities in the climbing fiber-Purkinje cell circuitry contribute to neuronal dysfunction in ATXN1[82Q] mice. J Neurosci 31:12778-89
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