Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS024204-08
Application #
2265102
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1988-08-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Allegheny University of Health Sciences
Department
Neurology
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19129
Romano, Gaetano; Macaluso, Marcella; Lucchetti, Chiara et al. (2007) Transcription and epigenetic profile of the promoter, first exon and first intron of the human tyrosine hydroxylase gene. J Cell Physiol 211:431-8
Jin, Hao; Romano, Gaetano; Marshall, Cheryl et al. (2006) Tyrosine hydroxylase gene regulation in human neuronal progenitor cells does not depend on Nurr1 as in the murine and rat systems. J Cell Physiol 207:49-57
Romano, Gaetano; Suon, Sokreine; Jin, Hao et al. (2005) Characterization of five evolutionary conserved regions of the human tyrosine hydroxylase (TH) promoter: implications for the engineering of a human TH minimal promoter assembled in a self-inactivating lentiviral vector system. J Cell Physiol 204:666-77
Yang, Ming; Donaldson, Angela E; Marshall, Cheryl E et al. (2004) Studies on the differentiation of dopaminergic traits in human neural progenitor cells in vitro and in vivo. Cell Transplant 13:535-47
Suon, Sokreine; Jin, Hao; Donaldson, Angela E et al. (2004) Transient differentiation of adult human bone marrow cells into neuron-like cells in culture: development of morphological and biochemical traits is mediated by different molecular mechanisms. Stem Cells Dev 13:625-35
Yang, Ming; Donaldson, Angela E; Jiang, Yubao et al. (2003) Factors influencing the differentiation of dopaminergic traits in transplanted neural stem cells. Cell Mol Neurobiol 23:851-64
Kessler, Mark A; Yang, Ming; Gollomp, Kandace L et al. (2003) The human tyrosine hydroxylase gene promoter. Brain Res Mol Brain Res 112:8-23
Yang, Ming; Stull, Natalie D; Berk, Mathew A et al. (2002) Neural stem cells spontaneously express dopaminergic traits after transplantation into the intact or 6-hydroxydopamine-lesioned rat. Exp Neurol 177:50-60
Iacovitti, L; Stull, N D; Jin, H (2001) Differentiation of human dopamine neurons from an embryonic carcinomal stem cell line. Brain Res 912:99-104
Stull, N D; Iacovitti, L (2001) Sonic hedgehog and FGF8: inadequate signals for the differentiation of a dopamine phenotype in mouse and human neurons in culture. Exp Neurol 169:36-43

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