Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS024679-10
Application #
2265312
Study Section
Neurology B Subcommittee 2 (NEUB)
Project Start
1987-04-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Werth, J L; Deshmukh, M; Cocabo, J et al. (2000) Reversible physiological alterations in sympathetic neurons deprived of NGF but protected from apoptosis by caspase inhibition or Bax deletion. Exp Neurol 161:203-11
Franklin, J L; Johnson, E M (1998) Control of neuronal size homeostasis by trophic factor-mediated coupling of protein degradation to protein synthesis. J Cell Biol 142:1313-24
Easton, R M; Johnson, E M; Creedon, D J (1998) Analysis of events leading to neuronal death after infection with E1-deficient adenoviral vectors. Mol Cell Neurosci 11:334-47
Easton, R M; Deckwerth, T L; Parsadanian, A S et al. (1997) Analysis of the mechanism of loss of trophic factor dependence associated with neuronal maturation: a phenotype indistinguishable from Bax deletion. J Neurosci 17:9656-66
Miller, T M; Moulder, K L; Knudson, C M et al. (1997) Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. J Cell Biol 139:205-17
Creedon, D J; Johnson, E M; Lawrence, J C (1996) Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival. J Biol Chem 271:20713-8
Deckwerth, T L; Elliott, J L; Knudson, C M et al. (1996) BAX is required for neuronal death after trophic factor deprivation and during development. Neuron 17:401-11
Miller, T M; Johnson Jr, E M (1996) Metabolic and genetic analyses of apoptosis in potassium/serum-deprived rat cerebellar granule cells. J Neurosci 16:7487-95
Deshmukh, M; Vasilakos, J; Deckwerth, T L et al. (1996) Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases. J Cell Biol 135:1341-54
Bullock, E D; Johnson Jr, E M (1996) Nerve growth factor induces the expression of certain cytokine genes and bcl-2 in mast cells. Potential role in survival promotion. J Biol Chem 271:27500-8

Showing the most recent 10 out of 28 publications