Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS025275-10
Application #
2265513
Study Section
Special Emphasis Panel (ZRG1-NLS-3 (01))
Project Start
1987-07-01
Project End
2001-04-30
Budget Start
1996-07-01
Budget End
1997-04-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Brusilow, Saul W; Koehler, Raymond C; Traystman, Richard J et al. (2010) Astrocyte glutamine synthetase: importance in hyperammonemic syndromes and potential target for therapy. Neurotherapeutics 7:452-70
Kawaguchi, Tetsu; Brusilow, Saul W; Traystman, Richard J et al. (2005) Glutamine-dependent inhibition of pial arteriolar dilation to acetylcholine with and without hyperammonemia in the rat. Am J Physiol Regul Integr Comp Physiol 288:R1612-9
Tanigami, H; Rebel, A; Martin, L J et al. (2005) Effect of glutamine synthetase inhibition on astrocyte swelling and altered astroglial protein expression during hyperammonemia in rats. Neuroscience 131:437-49
Brusilow, Saul W (2002) Hyperammonemic encephalopathy. Medicine (Baltimore) 81:240-9
Okada, T; Watanabe, Y; Brusilow, S W et al. (2000) Interaction of glutamine and arginine on cerebrovascular reactivity to hypercapnia. Am J Physiol Heart Circ Physiol 278:H1577-84
Hirata, T; Kawaguchi, T; Brusilow, S W et al. (1999) Preserved hypocapnic pial arteriolar constriction during hyperammonemia by glutamine synthetase inhibition. Am J Physiol 276:H456-63
Sugimoto, H; Koehler, R C; Wilson, D A et al. (1997) Methionine sulfoximine, a glutamine synthetase inhibitor, attenuates increased extracellular potassium activity during acute hyperammonemia. J Cereb Blood Flow Metab 17:44-9
Asano, Y; Koehler, R C; Kawaguchi, T et al. (1997) Pial arteriolar constriction to alpha 2-adrenergic agonist dexmedetomidine in the rat. Am J Physiol 272:H2547-56
Willard-Mack, C L; Koehler, R C; Hirata, T et al. (1996) Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat. Neuroscience 71:589-99
Hirata, T; Koehler, R C; Kawaguchi, T et al. (1996) Impaired pial arteriolar reactivity to hypercapnia during hyperammonemia depends on glutamine synthesis. Stroke 27:729-36

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