Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS025743-08S1
Application #
2265663
Study Section
Special Emphasis Panel (ZRG1-NLS-1 (01))
Project Start
1988-12-01
Project End
1998-01-31
Budget Start
1995-02-01
Budget End
1996-01-31
Support Year
8
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Psychiatry
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Jakubik, Jan; Janickova, Helena; Randakova, Alena et al. (2011) Subtype differences in pre-coupling of muscarinic acetylcholine receptors. PLoS One 6:e27732
Jakubík, J; Janí?ková, H; El-Fakahany, E E et al. (2011) Negative cooperativity in binding of muscarinic receptor agonists and GDP as a measure of agonist efficacy. Br J Pharmacol 162:1029-44
Grant, Marianne K O; Noetzel, Meredith J; De Lorme, Kayla C et al. (2010) Pharmacological evaluation of the long-term effects of xanomeline on the M(1) muscarinic acetylcholine receptor. PLoS One 5:e15722
Jakubík, Jan; El-Fakahany, Esam E (2010) Allosteric Modulation of Muscarinic Acetylcholine Receptors. Pharmaceuticals (Basel) 3:2838-2860
Michal, Pavel; Rudajev, Vladimír; El-Fakahany, Esam E et al. (2009) Membrane cholesterol content influences binding properties of muscarinic M2 receptors and differentially impacts activation of second messenger pathways. Eur J Pharmacol 606:50-60
Cabadak, Hulya; Cuadra, Adolfo E; El-Fakahany, Esam E et al. (2009) M2, M3, and M4 muscarinic receptors are expressed in the guinea pig gallbladder. J Recept Signal Transduct Res 29:63-6
Noetzel, Meredith J; Grant, Marianne K O; El-Fakahany, Esam E (2009) Immediate and delayed consequences of xanomeline wash-resistant binding at the M3 muscarinic receptor. Neurochem Res 34:1138-49
Noetzel, Meredith J; Grant, Marianne K O; El-Fakahany, Esam E (2009) Mechanisms of M3 muscarinic receptor regulation by wash-resistant xanomeline binding. Pharmacology 83:301-17
Kane, Brian E; Grant, Marianne K O; El-Fakahany, Esam E et al. (2008) Synthesis and evaluation of xanomeline analogs--probing the wash-resistant phenomenon at the M1 muscarinic acetylcholine receptor. Bioorg Med Chem 16:1376-92
De Lorme, Kayla C; Grant, Marianne K O; Noetzel, Meredith J et al. (2007) Long-term changes in the muscarinic M1 receptor induced by instantaneous formation of wash-resistant xanomeline-receptor complex. J Pharmacol Exp Ther 323:868-76

Showing the most recent 10 out of 93 publications