Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS026836-07
Application #
2266143
Study Section
Neurology B Subcommittee 2 (NEUB)
Project Start
1994-09-30
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Neurology
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Burke, Robert E; O'Malley, Karen (2013) Axon degeneration in Parkinson's disease. Exp Neurol 246:72-83
Chen, Xiqun; Tagliaferro, Patricia; Kareva, Tatyana et al. (2012) Neurotrophic effects of serum- and glucocorticoid-inducible kinase on adult murine mesencephalic dopamine neurons. J Neurosci 32:11299-308
Kim, Sang Ryong; Kareva, Tatyana; Yarygina, Olga et al. (2012) AAV transduction of dopamine neurons with constitutively active Rheb protects from neurodegeneration and mediates axon regrowth. Mol Ther 20:275-86
Kim, Sang Ryong; Ries, Vincent; Cheng, Hsiao-Chun et al. (2011) Age and ýý-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling. Neurobiol Dis 44:215-22
Kholodilov, Nikolai; Kim, Sang Ryong; Yarygina, Olga et al. (2011) Glial cell line-derived neurotrophic factor receptor-?1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra. J Neurochem 116:486-98
Cheng, Hsiao-Chun; Kim, Sang Ryong; Oo, Tinmarla F et al. (2011) Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy. J Neurosci 31:2125-35
Kim, Sang Ryong; Chen, Xiqun; Oo, Tinmarla F et al. (2011) Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration. Ann Neurol 70:110-20
Burke, Robert E (2010) Evaluation of the Braak staging scheme for Parkinson's disease: introduction to a panel presentation. Mov Disord 25 Suppl 1:S76-7
Cheng, Hsiao-Chun; Burke, Robert E (2010) The Wld(S) mutation delays anterograde, but not retrograde, axonal degeneration of the dopaminergic nigro-striatal pathway in vivo. J Neurochem 113:683-91
Cheng, Hsiao-Chun; Ulane, Christina M; Burke, Robert E (2010) Clinical progression in Parkinson disease and the neurobiology of axons. Ann Neurol 67:715-25

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