Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS027336-07
Application #
2266380
Study Section
Neurology C Study Section (NEUC)
Project Start
1989-04-01
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Saadat, Laleh; Dupree, Jeffrey L; Kilkus, John et al. (2010) Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT-deficient mice. Glia 58:391-8
Douglas, Darlene S; Popko, Brian (2009) Mouse forward genetics in the study of the peripheral nervous system and human peripheral neuropathy. Neurochem Res 34:124-37
Lin, Wensheng; Popko, Brian (2009) Endoplasmic reticulum stress in disorders of myelinating cells. Nat Neurosci 12:379-85
Douglas, Darlene S; Moran, Jennifer L; Bermingham Jr, John R et al. (2009) Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis. J Neurosci 29:12089-100
Traka, Maria; Wollmann, Robert L; Cerda, Sonia R et al. (2008) Nur7 is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS. J Neurosci 28:11537-49
Dupree, Jeffrey L; Mason, Jeffrey L; Marcus, Jill R et al. (2004) Oligodendrocytes assist in the maintenance of sodium channel clusters independent of the myelin sheath. Neuron Glia Biol 1:179-92
Ezoe, T; Vanier, M T; Oya, Y et al. (2000) Biochemistry and neuropathology of mice doubly deficient in synthesis and degradation of galactosylceramide. J Neurosci Res 59:170-8
Suzuki, K; Vanier, M T; Coetzee, T et al. (1999) Drastically abnormal gluco- and galactosylceramide composition does not affect ganglioside metabolism in the brain of mice deficient in galactosylceramide synthase. Neurochem Res 24:471-4