Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS027583-08
Application #
2266487
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1989-08-01
Project End
2001-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Oregon Graduate Institute Science & Tech
Department
Chemistry
Type
Other Domestic Higher Education
DUNS #
City
Beaverton
State
OR
Country
United States
Zip Code
97006
Chauhan, Shefali; Hosseinzadeh, Parisa; Lu, Yi et al. (2016) Stopped-Flow Studies of the Reduction of the Copper Centers Suggest a Bifurcated Electron Transfer Pathway in Peptidylglycine Monooxygenase. Biochemistry 55:2008-21
Park, Ga Young; Lee, Jung Yoon; Himes, Richard A et al. (2014) Copper-peptide complex structure and reactivity when found in conserved His-X(aa)-His sequences. J Am Chem Soc 136:12532-5
Chauhan, Shefali; Kline, Chelsey D; Mayfield, Mary et al. (2014) Binding of copper and silver to single-site variants of peptidylglycine monooxygenase reveals the structure and chemistry of the individual metal centers. Biochemistry 53:1069-80
Osborne, Robert L; Zhu, Hui; Iavarone, Anthony T et al. (2013) Interdomain long-range electron transfer becomes rate-limiting in the Y216A variant of tyramine ýý-monooxygenase. Biochemistry 52:1179-91
Kline, Chelsey D; Mayfield, Mary; Blackburn, Ninian J (2013) HHM motif at the CuH-site of peptidylglycine monooxygenase is a pH-dependent conformational switch. Biochemistry 52:2586-96
Otoikhian, Adenike; Barry, Amanda N; Mayfield, Mary et al. (2012) Lumenal loop M672-P707 of the Menkes protein (ATP7A) transfers copper to peptidylglycine monooxygenase. J Am Chem Soc 134:10458-68
Bauman, Andrew T; Broers, Brenda A; Kline, Chelsey D et al. (2011) A copper-methionine interaction controls the pH-dependent activation of peptidylglycine monooxygenase. Biochemistry 50:10819-28
Hess, Corinna R; Klinman, Judith P; Blackburn, Ninian J (2010) The copper centers of tyramine ?-monooxygenase and its catalytic-site methionine variants: an X-ray absorption study. J Biol Inorg Chem 15:1195-207
Himes, Richard A; Park, Ga Young; Siluvai, Gnana Sutha et al. (2008) Structural studies of copper(I) complexes of amyloid-beta peptide fragments: formation of two-coordinate bis(histidine) complexes. Angew Chem Int Ed Engl 47:9084-7
Himes, Richard A; Park, Ga Young; Barry, Amanda N et al. (2007) Synthesis and X-ray absorption spectroscopy structural studies of Cu(I) complexes of histidylhistidine peptides: the predominance of linear 2-coordinate geometry. J Am Chem Soc 129:5352-3

Showing the most recent 10 out of 28 publications