Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS027600-06
Application #
2266494
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1990-09-20
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of California Irvine
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Gennarino, Vincenzo A; Singh, Ravi K; White, Joshua J et al. (2015) Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels. Cell 160:1087-98
Carroll, Christopher L; Chamberlin, A Richard (2011) Synthesis of the dysiherbaine tetrahydropyran core utilizing improved tethered aminohydroxylation conditions. Tetrahedron Lett 52:3995-3997
Limon, Agenor; Reyes-Ruiz, Jorge M; Vaswani, Rishi G et al. (2010) Kaitocephalin antagonism of glutamate receptors expressed in Xenopus oocytes. ACS Chem Neurosci 1:175-181
Vaswani, Rishi G; Limon, Agenor; Reyes-Ruiz, Jorge Mauricio et al. (2009) Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-kaitocephalin. Bioorg Med Chem Lett 19:132-5
Okamura, Naoe; Habay, Stephen A; Zeng, Joanne et al. (2008) Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor. J Pharmacol Exp Ther 325:893-901
Vaswani, Rishi G; Chamberlin, A Richard (2008) Stereocontrolled total synthesis of (--)-kaitocephalin. J Org Chem 73:1661-81
Cohen, Jamie L; Chamberlin, A Richard (2007) Synthesis of the dysiherbaine tetrahydropyran core employing a tethered aminohydroxylation reaction. Tetrahedron Lett 48:2533-2536
Cohen, Jamie L; Chamberlin, A Richard (2007) Diastereoselective synthesis of glutamate-appended oxolane rings: synthesis of (s)-(+)-lycoperdic acid. J Org Chem 72:9240-7
Cohen, Jamie L; Limon, Agenor; Miledi, Ricardo et al. (2006) Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-dysiherbaine. Bioorg Med Chem Lett 16:2189-94
Esslinger, C Sean; Agarwal, Shailesh; Gerdes, John et al. (2005) The substituted aspartate analogue L-beta-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3. Neuropharmacology 49:850-61

Showing the most recent 10 out of 26 publications