Abstract

This is an application from a leading investigator in Borna disease virus (BDV) biology representing a competing renewal of a highly productive grant that represents the PI's major source of funding for basic research in BDV molecular biology and pathogenesis. The broad objective of the effort is to characterize BDV and to define viral and host factors that contribute to: (1) the low productivity of BDV infection, (2) its capacity to generate persistent infection, and (3) BDV neurotropism. The five specific aims include: (1) functional characterization of the BDV P protein, (2) analysis of BDV protein- protein interactions, (3) characterization of the BDV X protein, (4) isolation and characterization of cellular element (PRCE) binding proteins, and (5) establishment of a reverse genetic/recombinant BDV system.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS029425-08A1
Application #
2691791
Study Section
Experimental Virology Study Section (EVR)
Program Officer
Kerza-Kwiatecki, a P
Project Start
1991-05-01
Project End
2003-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
8
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of California Irvine
Department
Neurology
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Siemetzki, Ulrike; Ashok, Mundrigi S; Briese, Thomas et al. (2009) Identification of RNA instability elements in Borna disease virus. Virus Res 144:27-34
Williams, Brent L; Hornig, Mady; Yaddanapudi, Kavitha et al. (2008) Hippocampal poly(ADP-Ribose) polymerase 1 and caspase 3 activation in neonatal bornavirus infection. J Virol 82:1748-58
Williams, Brent L; Yaddanapudi, Kavitha; Hornig, Mady et al. (2007) Spatiotemporal analysis of purkinje cell degeneration relative to parasagittal expression domains in a model of neonatal viral infection. J Virol 81:2675-87
Williams, Brent L; Yaddanapudi, Kavitha; Kirk, Cassandra M et al. (2006) Metallothioneins and zinc dysregulation contribute to neurodevelopmental damage in a model of perinatal viral infection. Brain Pathol 16:1-14
Williams, B L; Lipkin, W I (2006) Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus. J Virol 80:8613-26
Macdonald, Joanne; Tonry, Jessica; Hall, Roy A et al. (2005) NS1 protein secretion during the acute phase of West Nile virus infection. J Virol 79:13924-33
Lipkin, W Ian; Hornig, Mady (2004) Psychotropic viruses. Curr Opin Microbiol 7:420-5
Hoffman, Kurt L; Hornig, Mady; Yaddanapudi, Kavitha et al. (2004) A murine model for neuropsychiatric disorders associated with group A beta-hemolytic streptococcal infection. J Neurosci 24:1780-91
Avellon, Ana; Casas, Inmaculada; Trallero, Gloria et al. (2003) Molecular analysis of echovirus 13 isolates and aseptic meningitis, Spain. Emerg Infect Dis 9:934-41
Briese, Thomas; Rambaut, Andrew; Pathmajeyan, Melissa et al. (2002) Phylogenetic analysis of a human isolate from the 2000 Israel West Nile virus epidemic. Emerg Infect Dis 8:528-31

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