The major focus of this research proposal is on the early processing and associated short-term storage of acoustic information. The mismatch negativity (MMN), an event-related potential (ERP) associated with sensory memory, will be the principal tool used in this endeavor. The proposed research will: (I) examine the manner in which information is stored in the memory; (2) evaluate reports that long term memory can facilitate the operation of sensory memory; (3) extend the finding that lip-read syllables can affect processing of concurrently spoken syllables in auditory cortex and thereby affect what is stored in sensory memory; (4) attempt to resolve a theoretical controversy concerning auditory regency effects by demonstrating that lip-read material (without accompanying sound) be entered into the memory; (5) inquire whether deaf subjects enter information acquired from lip-read and signed- speech signals into the memory; (6) examine in detail the scalp topography of auditory evoked potentials (AEP) and MMNs using scalp current density (SCD) mapping. The topographic mapping will define possible differential spatiotemporal patterns of the MNNs involved in the processing and storage of several aspects of auditory sensory information including frequency, intensity, duration, phonetic categorization and temporal patterning. These studies will test the hypothesis that the extent of cortical processing underling MMN generation differs for various stimulus features and for more complex comparisons involved in speech analysis and complex temporal sequences.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS030029-19
Application #
2037485
Study Section
Neurology A Study Section (NEUA)
Program Officer
Broman, Sarah H
Project Start
1977-05-01
Project End
1998-11-30
Budget Start
1996-12-01
Budget End
1997-11-30
Support Year
19
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Neurosciences
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
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De Sanctis, Pierfilippo; Ritter, Walter; Molholm, Sophie et al. (2008) Auditory scene analysis: the interaction of stimulation rate and frequency separation on pre-attentive grouping. Eur J Neurosci 27:1271-6
Saint-Amour, Dave; De Sanctis, Pierfilippo; Molholm, Sophie et al. (2007) Seeing voices: High-density electrical mapping and source-analysis of the multisensory mismatch negativity evoked during the McGurk illusion. Neuropsychologia 45:587-97
Ritter, Walter; De Sanctis, Pierfilippo; Molholm, Sophie et al. (2006) Preattentively grouped tones do not elicit MMN with respect to each other. Psychophysiology 43:423-30
Molholm, Sophie; Martinez, Antigona; Ritter, Walter et al. (2005) The neural circuitry of pre-attentive auditory change-detection: an fMRI study of pitch and duration mismatch negativity generators. Cereb Cortex 15:545-51
Frangos, Jason; Ritter, Walter; Friedman, David (2005) Brain potentials to sexually suggestive whistles show meaning modulates the mismatch negativity. Neuroreport 16:1313-7
Molholm, Sophie; Ritter, Walter; Javitt, Daniel C et al. (2004) Multisensory visual-auditory object recognition in humans: a high-density electrical mapping study. Cereb Cortex 14:452-65
Deacon, Diana; Dynowska, Anna; Ritter, Walter et al. (2004) Repetition and semantic priming of nonwords: implications for theories of N400 and word recognition. Psychophysiology 41:60-74
Winkler, Istvan; Sussman, Elyse; Tervaniemi, Mari et al. (2003) Preattentive auditory context effects. Cogn Affect Behav Neurosci 3:57-77
Sussman, Elyse; Winkler, Istvan; Kreuzer, Judith et al. (2002) Temporal integration: intentional sound discrimination does not modulate stimulus-driven processes in auditory event synthesis. Clin Neurophysiol 113:1909-20

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